BACKGROUND Gonadotropin-releasing hormone (GnRH) analogues are used routinely to prevent a premature luteinizing hormone (LH) surge in women undergoing assisted reproductive technology (ART) treatments. In contrast to GnRH agonists, antagonists produce rapid and reversible suppression of LH with no initial flare effect. OBJECTIVE To review the role of cetrorelix, the first GnRH antagonist app...

Successful IVF/ICSI treatment depends on obtaining a sufficient oocyte sample and selecting patients carefully. COH (Controlled Overian Hyperstimulation) treatment in patients with poor ovarian response is one of the most important issues in IVF programmes. The ovarian response that follows ovarian stimulation is the most important determiner in ART treatment. Although many other stimulation pr...

To compare the number of eggs, mature eggs and blastocysts obtained during stimulation in follicular phase (FP) versus stiulation luteal (LP) same menstrual cycle (DUOSTIM) patients with decreased ovarian reserve according to count visible antral follicles (AF) at time first oocyte retrieval. It was a Prospective paired observational study. From January 2020 March 2021, forty-nine women who wou...

Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially life-threatening complication of controlled ovarian stimulation (COS). OHSS is an iatrogenic complication of ovulation induction, which may cause serious impact on patient’s health. OHSS is the most feared complication of IVF-related ovarian stimulation, which in its severe form leads to hospitalization and in the worst case ...

BACKGROUND There has been much debate about the effect of 'residual' LH levels in normogonadotrophic women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH ovarian stimulation. The aim of this prospective study, where receiver-operating characteristic (ROC) analysis was used, was to assess further the usefulness of serum LH levels as predictors of ovarian r...

BACKGROUND New anticancer treatments have increased survival rates for cancer patients, but often at the cost of sterility. Several strategies are currently available for preserving fertility. However, the chances of achieving a pregnancy with one technique are still limited. A combination of methods is therefore recommended in order to maximize women's chances of future fertility. In this retr...

In the United States, ovarian cancer is the fourth most frequent cause of cancer death among women, following lung, breast, and colorectal cancers. Each year, approximately 26,000 women are diagnosed with ovarian cancer and 14,000 die of it. Germline mutations in BRCA1, BRCA2, or other genes have been implicated in a small fraction of cases. However, it has been suggested that, for the great ma...

BACKGROUND To test whether ovarian stimulation for in-vitro fertilization (IVF) affects oocyte quality and thus chromosome segregation behaviour during meiosis and early embryo development, preimplantation genetic screening of embryos was employed in a prospective, randomized controlled trial, comparing two ovarian stimulation regimens. METHODS Infertile patients under 38 years of age were ra...

Frog ovarian fragments were prevented from ovulating in vitro by the addition of actinomycin D up to 3 hr following pituitary stimulation; but addition of Actinomycin D 6 hr after stimulation was far less effective. Puromycin, on the other hand, effectively inhibited ovulation when added as late as 6 hr after pituitary stimulation. Although actinomycin D reduced uptake of uridine-(3)H, and puro...

Final oocyte maturation using GnRH-agonist trigger in a GnRH-antagonist protocol is increasingly common, as ovarian hyperstimulation syndrome is almost completely avoided. However, this approach might lead to reduced pregnancy rates due to severe luteolysis. This proof of concept study evaluated the extend of luteolysis by measuring progesterone levels 48 hours after oocyte retrieval in 51 pati...