OBJECTIVE To investigate the oocyte quality in patients with severe ovarian hyperstimulation syndrome (OHSS). DESIGN Self-controlled clinical study. SETTING University teaching hospital. PATIENT(S) Twenty-two patients from our assisted reproductive technology (ART) program who developed severe OHSS during their first controlled ovarian hyperstimulation for IVF or intracytoplasmic sperm in...

OBJECTIVE To compare two dosages of recombinant human follicle-stimulating hormone for controlled ovarian stimulation. DESIGN Prospective, randomised double-blind study. SETTING Tertiary assisted reproduction unit, Hong Kong. PARTICIPANTS Forty subfertile Chinese women aged 24 to 38 years undergoing in vitro fertilisation. Entry criteria included good physical and mental health, and a bod...

OBJECTIVE To report the first case of fertility preservation in a premenarcheal female by use of controlled ovarian hyperstimulation and oocyte cryopreservation. DESIGN Case report. SETTING Reproductive endocrinology and infertility unit of a tertiary care university-based medical center. PATIENT(S) A 13-year-old premenarcheal female with Tanner stage 3 breast development and Tanner stage...

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of ovarian stimulation, and the pathophysiological mechanisms that trigger the syndrome remain unknown. HCG increases serum vascular endothelial growth factor (VEGF) concentrations, and VEGF modulates transendothelial permeability via endothelial adherens junctions, a downstream target for VEGF signalling. We exam...

BACKGROUND Polycystic ovarian syndrome (PCOS) causes a significantly increased risk of ovarian hyperstimulation syndrome (OHSS). Here, we focused on the altered expression of serum miRNAs and their predictive value for OHSS in PCOS patients. METHODS We used the TaqMan low density array followed by individual quantitative reverse transcription-polymerase chain reaction to identify and validate...