INTRODUCTION Skeletal metastases are the most common complication of malignancies such as breast and prostate cancers [1]. In tumour-induced osteolysis, bone resorption is increased by the neoplastic activation of osteoclasts which results in rapid bone loss, change in the architectural integrity and ultimately, the load-bearing capacity of the affected bone. Fracture risk is increased by this ...

3. Information on permissions/orders of reprints in rheumatology and related fields. Silverman featuring research articles on clinical subjects from scientists working is a monthly international serial edited by Earl D.

A new experimental method to test the effect of drugs on tumor induced osteolysis using a transplantable bladder tumor (MBT-2) in mice has been designed. The method consists of inoculating tumor cells sc over the calvaria in mice, causing in a local tumor with fragmentation of the bone. This was accompanied by adjacent osteoblastic changes, which were evaluated by X-ray and histological examina...

The spatial distribution of single Au atoms on a thin FeO film has been investigated by low-temperature scanning tunneling microscopy and spectroscopy. The adatoms preferentially adsorb on distinct sites of the Moiré cell formed by the oxide layer and the Pt(111) support and arrange into a well-ordered hexagonal superlattice with 25 angstroms lattice constant. The self-organization is the conse...