The present study examined the development of anticipatory motor planning in an object manipulation task that has been used to successfully demonstrate motor planning in non-human primates (Weiss et al. in Psychol Sci 18:1063-1068, 2007). Seventy-five participants from four different age groups participated in a cup-manipulation task. One group was preschool children (average age of 5.1 years),...

the aim of the current study was to design a porous osmotic pump–based drug delivery system for controlling the release of buspirone from the delivery system. the osmotic pump was successfully developed using symmetric membrane coating. the core of the tablets was prepared by direct compression technique and coated using dip-coating technique. drug release from the osmotic system was studied us...

BACKGROUND Challenges in the diagnosis and classification of cholangiocarcinoma have made it difficult to quantify the true incidence of this highly aggressive malignancy. METHODS We analyzed the Surveillance, Epidemiology, and End Results data to assess long-term trends in the age-standardized incidence of intrahepatic and extrahepatic cholangiocarcinoma between 1973 and 2012, correcting for...

3563 Background: Molecular tumor profile assays (MTP) may predict the primary site of origin in CUP, but the impact of site-specific therapy on outcomes is undefined. Accurate identification of CUP patients (pts) with a colorectal site of origin would be expected to improve treatment results by directing the use of colorectal cancer regimens rather than empiric CUP regimens. METHODS We identi...

among the most common types of problematic soils, are probably the expansive ones. one of the modern methods of strengthening and improving the soil in place is the use of electro-osmotic improving treatment. this paper presents the design of an apparatus suitable for electro-osmotic treatment. a soil sample of a high expansive potential was compacted and the effect of electro-osmotic treatment...

Aims Patients’ advocates, regulators and doctors have the constant objective to make the best treatments quickly available to patients. Compassionate use programmes (CUP) as defined by the EU Regulation (EC) No 726/2004 article 83.2 are designed to provide early access before the marketing authorisation (MA) of a medicine. It is necessary to evaluate the achievements of the present legislations...

Cementless total hip replacement (THR) is rapidly being accepted as the surgery for arthritic diseases of the hip joint. The bone-ingrowth rate in porous-type cementless implants was about 90% over 10 years after surgery, showing that biological fixation of cementless THR was well maintained on both the stem and cup sides. As for the stress shielding of the femur operated using a distal fixatio...

abstract: the combination of pulsed vacuum osmotic dehydration and microwave drying of garlic bulbs were examined. the response surface methodology (rsm) was used to determine the effect of nacl concentration (8%-20%), osmotic solution temperature (25-65°c), operation pressure (240-830 mbar), immersion time (20-300 min) and microwave power level (100-600 w) on water loss (wl), solids gain (sg),...

in order to study of hydropriming and halopriming on germination and early growth stage of wheat (triticum aestivum l.) an experiment was carried out in laboratory of the department of agronomy and plant breeding, shahrood university of technology. seed treatments consisted of t1: control (untreated seeds), t2: soaking in distilled water for 18 h (hydropriming). t3: soaking in -1.2 mpa solution...

Low-pressure osmotic-based membrane separation, such as osmotic distillation (OMD) and forward osmosis (FO), is a separation process suitable for the concentration of liquid food with heat-sensitive components. In FO, dense hydrophilic used osmotic-pressure gradient driving force. Reverse salt diffusion low are major phenomena impeding FO application. Food preservatives can be applied draw solu...