Cells must respond sensitively to time-varying inputs in complex signaling environments. To understand how signaling networks process dynamic inputs into gene expression outputs and the role of noise in cellular information processing, we studied the immune pathway NF-κB under periodic cytokine inputs using microfluidic single-cell measurements and stochastic modeling. We find that NF-κB dynami...

A pressure based implicit procedure to solve the Euler and Navier-Stokes equation is developed to predict transonic viscous and inviscid flows around the pitching and heaving airfoils with a high reslution scheme. In this process, nonorthogonal and non moving mesh with collocated finite volume formulation are used. In order to simulate pitching or heaving airfoil, oscillation of flow boundary c...

The flight control responses of the fruitfly represent a powerful model system to explore neuromotor control mechanisms, whose system level control properties can be suitably characterized with a frequency response analysis. We characterized the lift response dynamics of tethered flying Drosophila in presence of vertically oscillating visual patterns, whose oscillation frequency we varied betwe...

We study the phase response properties of the PD neuron in the Stomato-gastric Ganglion (STG). We use model equations describing a square wave bursting oscillation to define and analyze the phase response dynamics for weak and strong perturbations. In the real and model neurons, we observe that the PRC saturates with amplitude. We show that for strong perturbations, much of the phase response i...

The human microbiomes across the body evidently interact with various signals in response to biogeographical physiological conditions. To understand such interactions in detail, we investigated how the salivary microbiome in the oral cavity would be regulated by host-related signals. Here, we show that the microbial abundance and gene participating in keeping the human salivary microbiome exhib...

[1] In this paper, we found that the Atlantic Multidecadal Oscillation (AMO) can contribute to the Pacific Decadal Oscillation (PDO), especially the component of the PDO that is linearly independent of El Niño and the Southern Oscillation (ENSO), i.e. the North Pacific Multidecadal Oscillation (NPMO), and the associated Pacific/North America (PNA) pattern. Using a hybrid version of the GFDL CM2...

A model of thalamocortical relay neuron is studied to assess whether a 7-14 Hz (spindle) oscillation and a 0.5-4 Hz (delta) oscillation may result from the interplay between a T-type calcium current and a non-specific cation sag current. With moderate change of membrane parameter values, the model neuron can exhibit both the spindle and delta rhythms, at different levels of hyperpolarization; o...

This study focuses on modeling the probe dynamics in scratching and indenting thin solid films at microand nanoscales. The model identifies bifurcation conditions that define the stick-slip oscillation patterns of the tip. It is found that the local energy fluctuations as a function of the inelastic deformation, defect formation, material properties, and contact parameters determine the oscilla...

The Main Injector Neutrino Oscillation Search (MINOS) experiment uses an acceleratorproduced neutrino beam to perform precision measurements of the neutrino oscillation parameters in the “atmospheric neutrino” sector associated with muon neutrino disappearance. This long-baseline experiment measures neutrino interactions in Fermilab’s NuMI neutrino beam with a near detector at Fermilab and agai...

The Main Injector Neutrino Oscillation Search (MINOS) experiment uses an acceleratorproduced neutrino beam to perform precision measurements of the neutrino oscillation parameters in the “atmospheric neutrino” sector associated with muon neutrino disappearance. This long-baseline experiment measures neutrino interactions in Fermilab’s NuMI neutrino beam with a near detector at Fermilab and agai...