TP53 mutations were analyzed in 35 human papillomavirus (HPV) type 16 DNA-positive cancers of the oral cavity and oropharynx and in 35 HPV DNA-negative cancers matched by subsite, country, sex, age, and tobacco and alcohol consumption. Wild-type TP53 was found more frequently in cancer specimens that contained HPV16 DNA than in those that did not. All 14 HPV16 DNA-positive cancers in HPV16 E6 a...

HNSCC: head and neck SCC SCC: squamous cell carcinoma SSS: secondary SCC of the skin INTRODUCTION Metastatic squamous cell carcinoma (SCC) to the skin, also known as secondary SCC of the skin (SSS), is a rare entity that represents advanced disease and carries a poor prognosis. The most commonly reported primary sources for metastatic SCC to the skin are head and neck cancers of the larynx, oro...

In order to assess if the use of the laryngeal mask airway is associated with an increased risk of gastric regurgitation during mechanical ventilation, we studied 50 patients allocated randomly to undergo anaesthesia with either artificial ventilation with isoflurane and nitrous oxide in oxygen and atracurium (group A) or spontaneous ventilation with isoflurane and nitrous oxide in oxygen (grou...

The purpose of this study was to compare the histopathological analysis with polymerase chain reaction (PCR) methods to predict the presence of human papillomavirus (HPV) infection in oral squamous cell carcinoma biopsies. Eighty-three paraffin-embedded tissue specimens from patients with oropharynx and mouth floor squamous cell carcinoma were submitted to histopathological analysis under light...

Immunosuppression of juvenile squirrel monkeys with combined azathioprine, prednisolone, and antilymphocyte globulin resulted in decreased antibody responses to viral antigens after primary infection with Herpesvirus saimiri (HVS). The virus was repeatedly isolated from the oropharynx of immunosuppressed monkeys but not from untreated infected controls. Thus immune factors are important in inhi...

Background The oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial lining of the oral cavity, accounting for about 95% of malignant lesions in this region. In Brazil, the oral cavity is the fifth location of the highest incidence of cancer in men and the seventh in women. In 2012, Brazil was estimated at 9,990 new cases of oral cancer in men and 4,180 in ...

Introduction: Head and neck cancers represent a major health problem in Hungary. With their high incidence mortality rates, Hungary is one of the world leaders these indicators. The length patient delay, defined as time from onset symptoms to first medical consultation, unknown Hungarian patients with head cancer. We aimed use representative sample cancer population determine delay according di...