Over the last few decades, significant efforts have been put forth towards C−H bond group functionalization by transition-metalcatalysis and organocatalysis. Several efficient strategies to convert C-H other groups C-C, C-N, C-O bonds implemented. The most attractive was heterocyclic compounds activation that is practical method in organic synthesis. new C–C, C–N C–O as formed from two diverse w...

Upon Brønsted base organocatalysis, ketone-derived alkylidene Meldrum's acids proved to be competent vinylogous platforms able undergo a formal (4+2) cycloaddition reaction with dihydro-2,3-furandione, providing an unprecedented route 3,6-dihydropyran-2-ones as spiro[4.5]decane derivatives up 98 % ee thanks the commercially available Takemoto catalyst. Preliminary investigation showed that this...