I n retrospect, the history of selenium biochemistry does not differ greatly from the study of a number of other trace elements in that it occurred over many years, progressing from periods of little general interest to widespread concern regarding toxicity problems and eventually to recognition of selenium as an essential nutrient for many forms of life. My involvement in studies on selenium m...

We conducted in vitro and in vivo assays in a selenium-deficient system to determine if organic matter (mainly fulvic acid; FA) is involved in a free radical mechanism of action for Kashin-Beck disease. Cartilage cell culture experiments indicated that the oxy or hydroxy functional groups in FA may interfere with the cell membrane and result in enhancement of lipid peroxidation. Experiments wit...

Selenium (Se) is an essential element for animals, including fish. Due to changes in feed composition for Atlantic salmon (Salmo salar), it may be necessary to supplement feeds with Se. In the present work, the transfer of Se and Se species from feed to muscle of Atlantic salmon fed Se supplemented diets was studied. Salmon were fed basal fish feed (0.35 mg Se/kg and 0.89 mg Se/kg feed), or fee...

Although recent reports suggest that selenium can modulate the activity of cytotoxic drugs, the mechanism underlying this activity remains unclear. This has been investigated using a panel of human B-cell lymphoma cell lines. The cytotoxic effects of chemotherapeutic agents (e.g., doxorubicin, etoposide, 4-hydroperoxycyclophosphamide, melphalan, and 1-beta-d-arabinofuranosylcytosine) were incre...

Magnesium and selenium belong to important bioelements. Magnesium is the second most abundant intracellular macroelement, which takes part in the metabolism of carbohydrates, nucleic acids, protein and lipids. Selenium is an essential microelement, whose deficit has been stated in many different pathological states. Much research on safe and effective selenium supplementation has been performed...

S research has been devoted to capturing the Sun’s energy with both inorganic and organic materials. Although the challenges are myriad, transformative discoveries in the latter class fall squarely in the realm of synthetic chemistry. Despite being lightweight, mechanically flexible, as well as easily and affordably processed, organic photovoltaics suffer from lower efficiencies and lifetimes t...

24 25 26 UN CO RR EC TE D PR Abstract. Selenium (Se) and arsenic are next-door neighbors on the periodic table and have similar chemical properties as metalloids. Arsenic antagonizes selenium toxicity in a number of organisms. Inorganic arsenic in drinking water is a human carcinogen while selenium compounds are anticarcinogenic in animals and humans. Our previous work showed that arsenite enha...