BACKGROUND Despite a genomic revolution in biological sciences, clinical medicine has yet to integrate diagnostics based upon gene expression into practice. While commonly used plasma protein assays rely on organ-specific origins, nearly all nucleic acid in whole blood is derived from white blood cells limiting their utility to diagnose non-immune disorders. The aim of the study was to use cell...

Gut mucosal injury observed during ischemia-reperfusion is believed to trigger a systemic inflammatory response leading to multiple organ failure. It should be interesting to demonstrate this relationship between gut and multiple organ failure in a sepsis model. Intestinal preconditioning (PC) can be used as a tool to assess the effect of intestinal ischemia in inflammatory response after LPS c...

Neutrophil activation is associated with the development of organ injury after trauma-hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma-hemorrhagic shock-induced hepatic and lung injuries in rats. In addition, administration of ursolic acid attenuated the hep...

OBJECTIVE To determine whether the progression and/or improvement of acute kidney injury in critically ill children is associated with mortality. DESIGN Retrospective. SETTING Multidisciplinary, tertiary care, 24-bed PICU. PATIENTS A TOTAL OF: 8,260 patients who were 1 month to 21 years old with no chronic kidney disease admitted between May 2003 and March 2012. INTERVENTIONS We analyze...

background: the term caustic generally refers to alkaline and the term corrosive generally refers to acidic agents' injury however, in medical literature caustic is frequently a term applied to both substances. ingested alkali typically damage the esophagus more than stomach or duodenum, whereas acids usually cause more severe gastric injury. since esophagus has a slightly alkaline ph, its...

Acute mesenteric ischemia (AMI) is a life-threatening condition that can result in multiple organ injury and death. A timely diagnosis and treatment would have a significant impact on the morbidity and mortality in high-risk patient population. The purpose of this study was to investigate if intestinal fatty acid binding protein (I-FABP) and α-defensins can be used as biomarkers for early AMI a...