OBJECTIVES Glutathione S-transferase (GST) A1 catalyses the activated heterocyclic aromatic a mine carcinogenN-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OAc-PhIP). This case-control study was carried out to examine whether the genetic polymorphism of GSTA1 is associated with the risk oforal squamous cell carcinoma among Japanese people in relation to their smoking status. MET...

background: the lysosomal protease cathepsin d (cd) has been associated with tumor progression in malignant tumors including oral squamous cell carcinoma (oscc). the purpose of this study was to find out any association between the cd and lymph node metastasis and to study the correlation of cd with various clinicopathological parameters to aid in assessment of its role as a prognostic indicato...

Introduction: Squamous cell carcinoma of the oral cavity is one of the most important and common types of head and neck malignancy, with an estimated rate of 4% among all human malignancies. The aim of this study was to determine the association between expression of matrix metalloproteinase 2 and 9 and the clinicopathological features of oral squamous cell carcinoma (OSCC).   Materials and Met...

stem cells are of great interest for regenerating disturbed tissues and organs. these cells are commonly isolated from the bone marrow, but there has been interest in other tissues in the recent years. in this study, we evaluated the possibility of isolation of stem cells from oral connective tissue and investigated their characteristics.in this experimental study, sampling from the bone marrow...

Bullous pemphigoid is a rare complication of immune checkpoint inhibitor treatment. We report case pembrolizumab-induced bullous in patient with malignant melanoma and concomitant cutaneous squamous cell carcinoma that regressed. A 77-year-old woman metastatic 3-year history growing skin nodule on her left calf was treated pembrolizumab. Histopathological examination the established diagnosis c...

Carcinomas are the major serious health issue in today’s healthcare system. while its prognosis is difficult at earlier stages. OSSC oral squamous cell carcinomas reported more than 3 lakhs new cases world-wide and it sixth most common cancer world-wide. Squamous carcinoma defined as of soft, flat, thin cells mainly affect soft regions like tongue diagnosed by various investigational imaging bi...

Introduction: Differentiation of fibroblasts to myofibroblasts is an initial and very important event in tumor genesis. Myofibroblasts produce proteinases that stimulate invasion in cancers. Due to the more malignant potential of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC) , the aim of the present study was to compare myofibroblasts between OSCC and ...

INTRODUCTION Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains un...