Parkinson’s disease (PD) is a progressive neurodegenerative that characterized by the loss of dopamine. Since dopamine has trouble entering blood–brain barrier, utilization dendrimers and other nanomaterials considered for conjugating neurotransmitter PD drugs. Dendrimers are three-dimensional, hyper-branched structures categorized into several generations. Alpha-synuclein (ASN) protein involve...

Aims & Scope: Biotechnology has provided a wide array of therapeutic agents such as peptide, protein, vaccine and gene products that are mainly administered by means of injections. Therapeutic agents produced by biotechnological processes such as recombinant DNA technology, fermentation, tissue and cell culture technology as well as genetic engineering are usually large, hydrophilic molecules f...

Trends and past achievements in the field of food colloids are reviewed. Specific mention is made of advances in knowledge and understanding in the areas of (i) structure and rheology of protein gels, (ii) properties of adsorbed protein layers, (iii) functionality derived from protein-polysaccharide interactions, and (iv) oral processing of food colloids. Amongst ongoing experimental developmen...

Mucosal immunization is advantageous over other routes of antigen delivery because it can induce both mucosal and systemic immune responses. Our goal was to develop a mucosal delivery vehicle based on bacteria generally regarded as safe, such as Lactobacillus spp. In this study, we used the Lyme disease mouse model as a proof of concept. We demonstrate that an oral vaccine based on live recombi...

The effective delivery and colonization of probiotics are recommended for therapeutic interventions during colitis, the efficacy which is hampered by abnormally colonized Enterobacteriaceae at pathological sites. To improve probiotics, a calcium tungstate microgel (CTM)-based oral probiotic system proposed herein. CTM can selectively disrupt ecological niche occupied expanded colitis to facilit...