Melanonychia commonly appears as a longitudinal band, starting from the matrix and extending to the tip of the nail plate. Less often it presents a transverse band or may inolve whole nail plate. Cutaneous side effects of hydroxyurea are described in 13% of patients including increased pigmentation, hyperkeratosis, skin atrophy, xerosis, lichenoid eruptions, palmar and plantar keratoderma, cuta...

BACKGROUND The diagnosis of fixed 'drug' eruption is not difficult for dermatologists, but it is difficult to identify the causative agent when the patient denies ingestion of any drugs. There have been some reported cases of fixed 'food' eruption. CASE SUMMARY A 71-year-old woman experienced repeated erythema and tense bulla with a burning sensation and pruritus on the right ankle. The erupt...

A personal trainer, 26 years of age, presented because of a 12-month history of secondary amenorrhoea since ceasing the oral contraceptive pill. In addition, a friend had commented on the yellow pigmentation of her hands, which had been present for an uncertain duration. Menarche occurred at 13 years of age, and menses had been regular prior to commencing the oral contraceptive pill for menorrh...

pipiens complex, were analyzed for morphological differentiation using multivariate techniques. Field-collected and laboratory-reared larvae of both species were compared for 12 morphometric characters. R. berlandieri larvae differ from R. sphenocephala larvae in having a more fusiform body shape, greater tail musculature development, a longer tail, relatively narrow dorsal and ventral tail fin...

Previously published Photo Quizzes are now featured in a mobile app. Get more information at http:// www.aafp.org/afp/apps. A 33-year-old man presented with asymptomatic blue-gray lesions on both feet. The lesions started developing six months earlier, getting darker and larger over time. He was using naproxen, tretinoin cream (Retin-A), and oral minocycline (Minocin). Physical examination reve...

ZinsserCole-Engman syndrome, also known as dyskeratosis congenita, is a rare genetic disorder characterized by triad of pigmentation and atrophy of the skin, leukokeratoses of oral mucosa and nail dystrophy along with bone marrow failure and predisposition to cancer [1]. The condition can be inherited as autosomal recessive, autosomal dominant and rarely X linked. It is proposed that mutations ...

Skin and hair pigmentation are two of the most easily visible examples of human phenotypic variation. Selection-based explanations for pigmentation variation in humans have focused on the relationship between melanin and ultraviolet radiation, which is largely dependent on latitude. In this study, skin and hair pigmentation were measured as the melanin (M) index, using narrow-band reflectance s...

Ocular pigmentation in white cats with blue and yellow eyes and in Siamese cats was examined ophthalmoscopically and histologically. Yellow-eyed white cats had entirely normal ocular pigmentation. Blue eyes of white cats had normal pigmentation of the iridial and retinal pigment epithelia but no stromal pigmentation of the iris or choroid. This deficit is apparently due to the absence of stroma...

Thirty-five of 41 asthmatic patients, who had been taking oral corticosteroids regularly for between one and 12 years, recovered their adrenal function after courses of depot tetracosactrin, even those with apparently complete adrenal suppression. They all showed benefit by transfer to depot tetracosactrin, though steroid withdrawal symptoms could be troublesome. Skin pigmentation in three, and...