OBJECTIVE To delineate the plasma pharmacokinetics and determine the corneal uptake of valine based stereoisomeric dipeptide prodrugs of acyclovir (ACV) in rats. METHODS Male Sprague-Dawley rats were used for the study. Pharmacokinetics of ACV, L-valine-acyclovir (LACV), L-valine-D-valine-acyclovir (LDACV) and D-valine-L-valine acyclovir (DLACV) prodrugs were delineated. These compounds were ...

Background: Premature neonates are hospitalized until they can get full mouth feeding and this often leads to increasing the hospitalization period. This study compared two neonatal care policies: early discharge of stable preterm infants with home gavage feeding and discharge when they reached to full oral feeding. Materials and Methods: By a case-control study, all stable premature neonates ...

Sea cucumber saponins have attracted more attention in recent years due to biological activities. It is popular practice soak sea Baijiu at home and being applied industrial manufacturing China. However, knowledge on the effect of alcohol absorption metabolism limited. The effects digestion, BALB/c mice were investigated after gavage tail intravenous injection. results showed that content serum...

Fernblock® is a standardized commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos promoted as an orally active photoprotective substance. In a previous battery of toxicological tests on Fernblock®, no genotoxicy was observed and no oral toxicity was observed up to 1200 mg/kg bw/day. The current study was conducted in Hsd.Han Wistar rats using doses of 0, 2000, ...

Methods Peanut allergy was induced in mice on the C57Bl/6 background (IA) with 4 weekly oral gavage feedings of peanut protein and cholera toxin. After a two-week rest period, sensitized animals were challenged by intraperitoneal injection with crude peanut extract (CPE) and monitored for anaphylaxis. Clinical indicators of peanut allergy include decreased body temperature, scratching, swollen ...

Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabet...

Tumor extracellular acidity is a hallmark of malignant cancers. Thus, in this study we evaluated the effects of the oral administration of a commercially available water alkalizer (Basenpulver®) (BP) on tumor growth in a syngenic melanoma mouse model. The alkalizer was administered daily by oral gavage starting one week after tumor implantation in CB57/BL mice. Tumors were calipered and their a...

Aim: Nickel, which has a wide usage area in industries, teratogenic, carcinogenic, immunotoxic, and genotoxic effects. In this study, the protective effects of lycopene, antioxidant properties, were investigated against genotoxicity caused by nickel sulfate. Materials Methods: total 24 rats (Wistar albino) divided into four groups: Group I (control) daily saline intraperitoneal (i.p.) corn oil ...