In patients with heart failure and disordered intracardiac conduction of activation, doctors implant a biventricular pacemaker (“cardiac resynchronization therapy”, CRT) to allow adjustment of the relative timings of activation of parts of the heart. The process of selecting the pacemaker timings that maximize cardiac function is called “optimization”. Although optimization—more than any other ...

Ground settlement is often the most serious concern when tunneling under an old city with numerous historic monuments. A successful engineering design under these conditions would require getting the most out of the ground strength parameters and avoiding any weakening maneuver throughout the operation. Knowing that surface settlement is highly affected by tunneling parameters in EPB shield tun...

In this study, the diffusivity and volumetric mass transfer coefficients for the extraction of β-carotene from crude palm oil using CO2 solvent in supercritical fluid were determined in the pressure range of 7.5-17.5 MPa and temperature range of 80-120 ºC. For this purpose, a statistical method was applied in order to minimize the number of experiments required. The volumetric ma...

The induced cracks on the concrete lining of the intake pressure tunnels may cause the water seep into the surrounding media leading to develop a hydro pressure on the external surface of the lining. In the common design practice, the lining can be designed to tolerate with this pressure using the Schleiss method. However, when the tunnel is constructed above the underground water, the seepage ...

In five unanesthetized dogs with surgical heart block, increasing ventricular rate from 50—75 to 250—300 beats/min demonstrated an optimum ventricular rate of 130 to 185, above which aortic pressure and cardiac output fell. In contrast, coronary blood flow continued to rise to a ventricular rate of 250 to 300 beats/min. Stroke systolic coronary flow was well maintained over the entire range of ...