Importância dos intervalos entre as doses de medicamentos.

BACKGROUND Intradermal (ID) delivery has been shown to accelerate insulin pharmacokinetics (PK). We compared the PK and pharmacodynamic (PD) effects of insulin lispro administered before two daily standardized solid mixed meals (breakfast and lunch), using microneedle-based ID or traditional subcutaneous (SC) delivery. METHOD The study included 22 subjects with type 1 diabetes in an eight-arm...

BACKGROUND The incidences of morbidity and mortality caused by pharmacosedation for dental treatment have not yet reached zero. Adverse events are related to inappropriate respiratory management, mostly originating from an overdose of sedatives. Since sedation is utilized for the satisfaction of both the dentist and the patient, the optimal dose should be minimized to prevent adverse events. We...

Background: Therapeutic drug monitoring (TDM) involves the measurement of serum concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used evaluate antihypertensive response. However, approximately 50% hypertensive patients treated with lifestyle changes drugs fail achieve control. Serum concentration could be useful select optimal ...

Abstract The choice of modern technologies at the enterprises agroindustrial complex allows ensuring safety and high quality indicators food products. spread industrial ionizing radiation treatment technology requires compliance with procedural processes in specialized centers. To ensure preservation raw meat, particular chilled beef, after radiation, it is scientific practical importance to su...

In this study, we aimed to evaluate the feasibility of digital image analysis (DIA) as a substitute for standard (SA) in assessing corn ear traits agrotechnical field trials. Accurate and timely prediction yield through can lead precise agricultural management recommendations improvement production. Four replications with 10 plots each were subjected different fertilization regimes analyzed usi...

BACKGROUND: When studying new and effective methods of treating acute respiratory distress syndrome, an immunogenic model lung injury occupies a special place. To date, the search for optimal strategy regimen use glucocorticoids in development syndromе is relevant.
 AIM: The article evaluates effectiveness various schemes systemic anti-inflammatory therapy with experimental LPS-induced inj...