Optical imaging in a highly scattering medium is effective only at very shallow depths which limits its use as a diagnostic tool in biomedical imaging, particularly for tumor detection. By combining optical and acoustic modalities, high-contrast, tumor state-relevant optical information at higher spatial resolutions can be achieved. Hybrid imaging modalities such as acousto-optic and photoacous...

A novel optical frequency-domain imaging system is demonstrated that employs a passive optical demodulation circuit and a chirped digital acquisition clock derived from a voltage-controlled oscillator. The demodulation circuit allows the separation of signals from positive and negative depths to better than 50 dB, thereby eliminating depth degeneracy and doubling the imaging depth range. Our sy...

Optical brain imaging has seen 30 years of intense development, and has grown into a rich and diverse field. In-vivo imaging using light provides unprecedented sensitivity to functional changes through intrinsic contrast, and is rapidly exploiting the growing availability of exogenous optical contrast agents. Light can be used to image microscopic structure and function in vivo in exposed anima...

Biomedical optics is a rapidly emerging field for medical imaging and diagnostics. This paper reviews several biomedical optical technologies that have been developed and translated for either clinical or pre-clinical applications. Specifically, we focus on the following technologies: 1) near-infrared spectroscopy and tomography, 2) optical coherence tomography, 3) fluorescence spectroscopy and...

Different optical-based imaging models were used to investigate tumor progression and metastasis with particular emphasis on metastasis to bone and bone marrow. We describe how optical imaging can be used to follow important processes in tumor development and treatment response, including angiogenesis, apoptosis, and proteolysis. Finally, we discuss the translation of one optical imaging modali...

Optical impulse-response characterization of diffusive media can be of importance in various applications, among them optical imaging in the security and medical fields. We present results of an experimental technique that we developed for acquiring the impulse response, based upon the Kramers-Kronig algorithm, and have been applied for optical imaging of objects hidden behind clothing. We demo...

Cancer is a major threat to human health. Diagnosis and treatment using precision medicine is expected to be an effective method for preventing the initiation and progression of cancer. Although anatomical and functional imaging techniques such as radiography, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have played an important role for accu...

Imaging and detection of objects at optical wavelengths offers better resolution than at microwave or millimeter wavelengths. However, the imaging is severely affected by scattering from fog and clouds. This paper presents a study of optical imaging through clouds by using the point-source vector radiative transfer theory. The point-spread function including complete polarization characteristic...

Previous methods for analyzing optical imaging data have relied heavily on temporal averaging. However, response dynamics are rich sources of information. Here, we develop and present a method that combines principal component analysis and multitaper harmonic analysis to extract the statistically significant spatial and temporal response from optical imaging data. We apply the method to both si...

In vivo molecular imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems. Among the methodologies used in in vivo molecular imaging, two methodologies are of great interest from the view of high sensitivity. One is nuclear medical imaging, and distribution and kinetics of a radiolabeled mole...