Advances in optical imaging modalities, such as optical coherence tomography (OCT), enable us to observe tissue microstructure at high resolution and in real time. Currently, core-needle biopsies are guided by external imaging modalities such as ultrasound imaging and x-ray computed tomography (CT) for breast and lung masses, respectively. These image-guided procedures are frequently limited by...

Optical coherence tomography is a new technology that provides an atraumatic "optical biopsy" providing both anatomical and possible histopathologic results. It has only recently been incorporated into the urological field. This paper highlights previous and prospective advances of optical coherence tomography in urology and its potential application in robotic urologic surgery.

Choroidal osteoma (CO) is a rare, ossifying benign tumor originated in the choroid that typically occurs in otherwise healthy young women (1,2). It is characterized by a yellowish, well demarcated lesion in the juxtapapillary or macular area. The diagnosis is clinical and can be confirmed with the use of fluorescein or indocyanine angiography, optical coherence tomography, computed tomography o...

Optical coherence tomography (OCT) delivers 3-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution method, OCT images experience some artifacts that lead to misapprehension of tissue structures. Speckle, intensity decay, and blurring are 3 major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of ...

Three-dimensional high-resolution imaging methods are important for cellular-level research. Optical coherence microscopy (OCM) is a low-coherence-based interferometry technology for cellular imaging with both high axial and lateral resolution. Using a high-numerical-aperture objective, OCM normally has a shallow depth of field and requires scanning the focus through the entire region of intere...

As imaging systems become more advanced and acquire data at faster rates, increasingly dynamic samples can be imaged without concern of motion artifacts. For optical interferometric techniques such as optical coherence tomography, it often follows that initially, only amplitude-based data are utilized due to unstable or unreliable phase measurements. As systems progress, stable phase maps can a...

Optical-resolution photoacoustic microscopy is becoming a powerful research tool for studying microcirculation in vivo. Moreover, ultrasonic-array-based optical-resolution photoacoustic computed tomography (OR-PACT), providing comparable resolution at an improved speed, has opened up new opportunities for studying microvascular dynamics. In this Letter, we have developed a compressed sensing wi...

Optical systems capable of three-dimensional transmission imaging are considered; these systems employ a conventional tomographic setup with an added linear shift-invariant optical system between the sample and the detector. A theoretical analysis is presented of image formation and sample reconstruction in such systems, examples of which include diffraction tomography and phase-contrast tomogr...