نتایج جستجو برای: optic pathway glioma
تعداد نتایج: 389384 فیلتر نتایج به سال:
OBJECTIVE The goal of the Response Evaluation in Neurofibromatosis and Schwannomatosis Visual Outcomes Committee is to define the best functional outcome measures for future neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG) clinical trials. METHODS The committee considered the components of vision, other ophthalmologic parameters affected by OPG, potential biomarkers of vis...
BACKGROUND We wanted to determine the sensitivity and specificity of serial changes in visual acuity and visual evoked potentials (VEPs) to detect radiological progression of tumor volume in children with optic pathway gliomas. METHODS From a retrospective review of a cohort of 69 patients, 54 patients met inclusion criteria (31 with primary chemotherapy, 4 with primary radiotherapy, and 19 w...
In his very informative and thoughtful discussion of a patient with copper deficiency, Dr Samuels refers to the checklist concept in considering the differential diagnosis. He cites a Google search of myeloneuropathy and malnutrition as helping in suggesting the diagnosis. He further notes that searching on common nonspecific neurologic signs and symptoms generates exhaustive lists that would n...
BACKGROUND In terms of overall survival (OS), limited data are available for the very long-term outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy. Therefore, we undertook this study with the aim of clarifying long-term OS and causes of death in these patients. METHODS We initiated and analyzed a historical cohort study of 180 children with OPG treated in F...
The prognosis of glioma patients is usually poor, especially in patients with glioblastoma (World Health Organization (WHO) grade IV). The regulatory functions of microRNA (miRNA) on genes have important implications in glioma cell survival. However, there are not many studies that have investigated glioma survival by integrating miRNAs and genes while also considering pathway structure. In thi...
Sir, We read with great interest the article by Gelfand et al. (2012) in the June issue of Brain. The authors described in detail vacuolar macular changes in the inner nuclear layer of patients with multiple sclerosis. This ‘microcystic macular oedema’ was associated with decreased visual acuity and a higher disability score. We found similar microcysts in the macular inner nuclear layer of a 1...
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