Purpose: An epidemic of subacute optic neuropathy with sensori-neural hearing loss and peripheral neuropathy has affected Tanzania. The primary objective of this thesis was:To describe the clinical features of the disease. To describe the magnitude of the epidemic To investigate the aetiology of the disease To determine if daily oral B-complex supplements improved prognosis. Methods: 225 acute ...

BACKGROUND Diagnosis of traumatic optic neuropathy is difficult during primary care as a result of the absence of optic disk changes or coexisting injuries that may be more apparent. Although there are functional signs that suggest its presence, the lack of a comparison parameter may further prevent its detection. A case of bilateral traumatic optic neuropathy is analyzed to emphasize the need ...

AIM To study the normal distributions of mitochondria and voltage gated Na+ channels in the human optic nerve head in order to gain insight into the potential mechanisms of optic nerve dysfunction seen in the inherited optic neuropathies. METHODS Five fresh frozen human optic nerves were studied. Longitudinally orientated, serial cryosections of optic nerve head were cut for mitochondrial enz...

BACKGROUND We conducted this study to report the demographics and clinical profile of patients with nonarteritic anterior ischemic optic neuropathy referred to a referral neuro-ophthalmology center in Iran. METHODS During a five-year period, 107 patients with nonarteritic anterior ischemic optic neuropathy were studied. A detailed history of previous or current systemic diseases was obtained ...