نتایج جستجو برای: opn gene

تعداد نتایج: 1142210  

1998
Jeffrey B. Safran William T. Butler Mary C. Farach-Carson

In osteoblastic ROS 17/2.8 cells, 1,25-(OH)2-vitamin D3 stimulates transcription of the extracellular matrix phosphoprotein osteopontin (OPN). We now show posttranslational regulation of OPN production by 1,25(OH)2D3. Prior to transcriptional up-regulation of OPN, 1,25-(OH)2D3 induces a shift in OPN isoelectric point (pI) from 4.6 to 5.1. Loading equal amounts of OPN recovered from ROS 17/2.8 c...

Journal: :American journal of physiology. Renal physiology 2011
Jun Irita Takafumi Okura Masanori Jotoku Tomoaki Nagao Daijiro Enomoto Mie Kurata Veena Rasika Desilva Ken-Ichi Miyoshi Yutaka Matsui Toshimitsu Uede David T Denhardt Susan R Rittiling Jitsuo Higaki

Osteopontin (OPN) has been implicated in the pathology of several renal conditions. Recently, we demonstrated in vitro that aldosterone has important roles in collagen synthesis by inducing OPN (Irita J, Okura T, Kurata M, Miyoshi K, Fukuoka T, Higaki J. Hypertension 51: 507-513, 2008). The aim of the present study was to clarify the roles of OPN in aldosterone-mediated renal fibrosis by infusi...

Journal: :Cancer research 1993
A F Chambers C Hota C W Prince

We previously reported that H-ras-induced metastatic ability in murine NIH 3T3 cells is accompanied by increased expression of osteopontin (OPN). OPN is a secreted phosphoprotein that contains a GRGDS amino acid sequence, suggesting adhesive function, but the function of OPN in tumor cells remains poorly understood. Here we report that PAP2 cells (ras-transformed, metastatic NIH 3T3 cells) adhe...

Journal: :The Journal of Experimental Medicine 2002
Mei Y. Speer Marc D. McKee Robert E. Guldberg Lucy Liaw Hsueh-Ying Yang Elyse Tung Gerard Karsenty Cecilia M. Giachelli

Osteopontin (OPN) is abundantly expressed in human calcified arteries. To examine the role of OPN in vascular calcification, OPN mutant mice were crossed with matrix Gla protein (MGP) mutant mice. Mice deficient in MGP alone (MGP(-/-) OPN(+/+)) showed calcification of their arteries as early as 2 weeks (wk) after birth (0.33 +/- 0.01 mmol/g dry weight), and the expression of OPN in the calcifie...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Marta Scatena Lucy Liaw Cecilia M Giachelli

Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory and autoimmune diseases, and it is specifically localized in and around inflammatory cells. OPN is a secreted adhesive molecule, and it is thought to aid in the recruitment of monocytes-macrophages and to regulate cytokine production in macrophages, dendritic cells, and T-cells. OPN has been classified as T...

2014
Maria Cecilia Garibaldi Marcondes Ryan Ojakian Nikki Bortell Claudia Flynn Bruno Conti Howard S. Fox

Upregulation of osteopontin (OPN) is a characteristic of central nervous system pathologies. However, the role of OPN in inflammation is still controversial, since it can both prevent cell death and induce the migration of potentially damaging inflammatory cells. To understand the role of OPN in inflammation and cell survival, we expressed OPN, utilizing an adenoviral vector, in the caudoputame...

2017
Soo Im Choi Seo Yoen Kim Jei Ha Lee Jung Yul Kim Eun Wie Cho In-Gyu Kim

Transmembrane 4 L6 family proteins have been known to promote cancer. In this study, we demonstrated that transmembrane 4 L6 family member 4 (TM4SF4), which is induced by γ-radiation in non-small cell lung cancer (NSCLC) cells, is involved in epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) properties of NSCLC through the regulation of osteopontin (OPN). Forced TM4SF4 overe...

Journal: :The Journal of clinical investigation 2005
Guangwu Xu Hong Nie Ningli Li Wenxin Zheng Dongqing Zhang Guozhang Feng Liqing Ni Rong Xu Jian Hong Jingwu Z Zhang

Osteopontin (OPN) is an extracellular matrix protein of pleiotropic properties and has been recently recognized as a potential inflammatory cytokine. In this study, we demonstrate, for the first time to our knowledge, that overexpression of OPN in synovial T cells is associated with local inflammatory milieu and that OPN acts as an important mediator in amplification and perpetuation of rheumat...

2016
Michael Sponder Christian Reuter Monika Fritzer-Szekeres Brigitte Litschauer Thomas Binder Jeanette Strametz-Juranek

BACKGROUND Osteopontin (OPN) regulates the Ca(++)-deposition in bone and coronary arteries. Elevated OPN were also associated with (aortic) valve calcification in healthy individuals. This study aimed to investigate the association between OPN levels and mitral annulus calcification (MAC) in patients with coronary artery disease (CAD). METHODS In this cross-sectional study OPN-levels were mea...

2012
Stéphanie Patouraux Stéphanie Bonnafous Cosmin S. Voican Rodolphe Anty Marie-Christine Saint-Paul Maria-Alessandra Rosenthal-Allieri Hélène Agostini Micheline Njike Nadége Barri-Ova Sylvie Naveau Yannick Le Marchand-Brustel Pascal Veillon Paul Calès Gabriel Perlemuter Albert Tran Philippe Gual

BACKGROUND Osteopontin (OPN) plays an important role in the progression of chronic liver diseases. We aimed to quantify the liver, adipose tissue and serum levels of OPN in heavy alcohol drinkers and to compare them with the histological severity of hepatic inflammation and fibrosis. METHODOLOGY/PRINCIPAL FINDINGS OPN was evaluated in the serum of a retrospective and prospective group of 109 ...

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