نتایج جستجو برای: opioid addiction

تعداد نتایج: 52416  

2014
Monica Bawor Brittany B Dennis Rebecca Anglin Meir Steiner Lehana Thabane Zainab Samaan

BACKGROUND Use of methadone for the treatment of opioid addiction is an effective harm-reduction approach, although variability in treatment outcomes among individuals has been reported. Men and women with opioid addiction have been known to differ in factors such as opioid use patterns and characteristics at treatment entry; however, little has been reported about differences in methadone trea...

Journal: :Biological psychiatry 2015
Dana B Hancock Joshua L Levy Nathan C Gaddis Cristie Glasheen Nancy L Saccone Grier P Page Gary K Hulse Dieter Wildenauer Erin A Kelty Sibylle G Schwab Louisa Degenhardt Nicholas G Martin Grant W Montgomery John Attia Elizabeth G Holliday Mark McEvoy Rodney J Scott Laura J Bierut Elliot C Nelson Alex H Kral Eric O Johnson

BACKGROUND No opioid receptor, mu 1 (OPRM1) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been conclusively associated with heroin/other opioid addiction, despite their biological plausibility. We used evidence of polymorphisms altering OPRM1 expression in normal human brain tissue to nominate and then test associations with heroin addiction. ...

2014
Zainab Samaan Monica Bawor Brittany B Dennis Carolyn Plater Michael Varenbut Jeffrey Daiter Andrew Worster David C Marsh Charlie Tan Dipika Desai Lehana Thabane Guillaume Pare

INTRODUCTION Treatment of opioid addiction with methadone is effective; however, it is known to produce interindividual variability. This may be influenced in part by genetic variants, which can increase the initial risk of developing opioid addiction as well as explain differences in response to treatment. This pilot study aimed to assess the feasibility of conducting a full-scale genetic anal...

Journal: :Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2007
Joel E Dimsdale Daniel Norman Douglas DeJardin Mark S Wallace

STUDY OBJECTIVES The effect of opioid medications on sleep architecture has been demonstrated in patients with comorbid pain or opioid addiction. This study examined whether commonly used opioid medications have an adverse effect on sleep architecture in healthy adults. METHODS Forty-two healthy subjects were examined with polysomnography after a bedtime dose of placebo, sustained-release mor...

2015
Caroline J. Jolley James Bell Gerrard F. Rafferty John Moxham John Strang Gabriele Fischer

Opioids are respiratory depressants and heroin/opioid overdose is a major contributor to the excess mortality of heroin addicts. The individual and situational variability of respiratory depression caused by intravenous heroin is poorly understood. This study used advanced respiratory monitoring to follow the time course and severity of acute opioid-induced respiratory depression. 10 patients (...

2017
Valerie M. Hewell Angel R. Vasquez Inna D. Rivkin

BACKGROUND Opioid use is a significant problem in Alaska. Medication-assisted treatment for opioid use, including buprenorphine, reduces withdrawal symptoms and the harm associated with opioid abuse. Understanding consumers' treatment-seeking process is important for addressing barriers to treatment, facilitating effective service utilization, and informing policy. METHODS To understand treat...

Journal: :Recent patents on CNS drug discovery 2010
Lindsay H Burns Hoau-Yan Wang

Binding a critical pentapeptide region on the scaffolding protein filamin A regulates signaling of mu opioid receptors (MORs) so that their activation should not result in the opioid tolerance, dependence and addiction associated with current opioid painkillers. Additionally, we show that compounds that bind this site on filamin A reduce release of inflammatory cytokines. PTI-609 is a new chemi...

Journal: :Journal of Ayub Medical College, Abbottabad : JAMC 2008
Sibghatullah Sangi Shahida P Ahmed Muhammad Aslam Channa Muhammad Ashfaq Shah Murad Mastoi

BACKGROUND Opioid dependence is one of the major social and psychiatric problem of society. Unfortunately there is no non opiate treatment available. For centuries man has used plants for their healing proprieties. These plants play a fundamental part in all treatment modalities, both ancient and modern. METHODS This study was conducted to find non opiate treatment for opiate withdrawal. Tota...

Journal: :The Medical clinics of North America 2007
Grace Chang Lucy Chen Jianren Mao

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and d...

Journal: :Pain physician 2016
Mark V Boswell

It appears that the medical specialty of pain medicine is a victim of its own success. With the increasing demand for chronic pain management, pain physicians are pressured to prescribe ever-increasing amounts of opioids. However, there is compelling evidence that pervasive opioid availability is driving opioid misuse, diversion, and addiction. As a result, pain physicians are often caught up i...

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