BACKGROUND Healthy individuals performing response suppression tasks activate anterior cingulate cortex with occurrence of false alarm error responses to nontargets. Fundamental questions include whether this error-related activation provides a signal contributing to behavioral control and, given generally poorer performance on such tasks by addicts, whether this signal is disrupted in addictio...

Opiate addiction is a chronic mental illness with severe repercussion in personal and public health. Various medicaments have been subjected to research in order to find a proper treatment, methadone is the most and wide used drug, buprenorphine/naloxone is the most recent ones, but other choices have been proposed such as prescribing heroin (1). The mentioned treatments, are considered as main...

INTRODUCTION The diagnosis of psychoactive substance use disorders has been based primarily on descriptive, symptomatic checklist criteria. In opioid addiction, there are no objective biological indicators specific enough to guide diagnosis, monitor disease status, and evaluate efficacy of therapeutic interventions. Proton magnetic resonance spectroscopy (1H MRS) of the brain has potential to i...

Chronic opiate exposure is associated with upregulation of the cAMP signaling pathway and the transcription factor cAMP response element-binding protein in the locus ceruleus (LC) and certain other brain areas. To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and perform...

Evidence of the misuse of dihydrocodeine preparations remains largely anecdotal,' 2consisting of case reports of dependence mainly among users of the proprietary form of dihydrocodeine tartrate DF 118. Recent estimates of the extent of dihydrocodeine misuse in the general population and among drug users are lacking. This paper reports the results of an investigation into the level of DF 118 mis...

SUMMARY Despite record-breaking numbers of opiate related deaths in the UK 2019, pharmacological management dependence has evolved little since advent methadone 1965. Along with harm minimisation and psychosocial interventions, mainstay treatment remains opioid substitution therapy (OST) using or buprenorphine, many patients receiving OST for years. Even these treatments, users continue to face...

In France, high-dosage buprenorphine (HDB) is the main substitution treatment for narcotic addiction. Few data have been published concerning clinical factors predicting a good response to this treatment in a daily practice. A hospital-based multicenter clinical research program (PHRC) was undertaken in heroin-addicted patients, diagnosed according to DSM-III-R, to detect clinical criteria susc...

Memorial Symposium In Memoriam: Abraham Wikler and H. Frank Fraser--Introductory Remarks Jerome H. Jaffe 14 A Steric Theory of Opioid Agonists, Antagonists, AgonistAntagonists, and Partial Agonists William R. Martin 16 Environmental Influences in the Perception of Pain Conan Kornetsky 24 Classical Conoitioning in Opiate Dependence Charles P. O'Brien, Ronald N. Ehrman, and Joseph W. Ternes 35 On...