Abstract Introduction: Thalassemia is the most common hereditary anemia in Iran. The aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins IgG, IgM, and IgA and complement components in patients with major thalassemia. Materials and Methods: This interventional semi-experimental study (before-after) was performed...

Introduction: Splenectomy has long been used to treat benign hematological abnormalities such as immune thrombocytopenia (ITP), some hemolytic anemias- especially hereditary spherocytosis and thalassemia, prehepatic portal hypertension. The discovery that splenectomized individuals are more vulnerable encapsulated organism infection attributed the spleen's lack of filtration development anticar...

By DONALD SHOTTON, M.D., CHARLES L. CROCKETT, JR. M.D.* BYRD S. LEAVELL, M.D. S ICKLE CELL ANEMIA was described first 1)y Heriick’ in 1910. Although the disease was considered to be hemolytic in nature and many of the early patients had splenomegahy, splenectomy in this condition was reported first by Hahn and Gillespie2 in 1927. Since that time the literature on splenectomy in this disease has...

BACKGROUND AND OBJECTIVES Laparoscopic surgical techniques in pregnancy have been accepted and pose minimal risks to the patient and fetus. We present the first reported case of a pregnant woman with immune thrombocytopenia purpura who underwent laparoscopic splenectomy during the second trimester. METHODS AND RESULTS The anesthesia, hematology, and obstetrics services closely followed the pa...

Clinical manifestations of hereditary spherocytosis (HS) can be abrogated by splenectomy. However, concerns exist regarding exposure of patients to a lifelong risk for overwhelming infections and, to a lesser extent, to vascular complications after total splenectomy. In the search for alternative treatment modalities, we assessed, in a previous pilot study, the potential usefulness of subtotal ...

BACKGROUND AND OBJECTIVES We present 2 cases of laparoendoscopic single site surgery (LESS) splenectomy performed with a conventional laparoscope and instruments, and the use of a novel internal retraction device. METHODS One patient underwent LESS splenectomy for idiopathic thrombocytopenia purpura (ITP), and a pediatric patient with sickle cell disease underwent LESS splenectomy and cholec...

Splenectomy has been a standard treatment for adult patients with idiopathic thrombocytopenic purpura (ITP) for more than 50 years. However, the durability of responses, the ability to predict who will respond, and the frequency of surgical complications with splenectomy all remain uncertain. To better interpret current knowledge we systematically identified and reviewed all 135 case series, 19...