To the Editor: We read with great interest the Case Scenario on hypoxemia during one-lung ventilation (OLV) reported by Rozé et al., and we would like to add some comments on pharmacological treatment. First, the title of the section, “Pharmacological treatment to limit hypoxic pulmonary vasoconstriction,” could, in our opinion, lead to confusion. Almitrine does not limit hypoxic pulmonary vaso...

We present 2 cases of severe re-expansion pulmonary edema (RPE) after one-lung ventilation (OLV) for thoracic surgery. A 32-y-old woman with multiple lung metastases developed severe RPE after OLV during lung resection surgery. A 37-y-old man with infective endocarditis also developed severe RPE after OLV for mitral valve plasty with minimally invasive cardiac surgery. In both cases, results of...

BACKGROUND Double-lumen tubes (DLTs) are frequently used to establish one-lung ventilation (OLV). Their correct placement is crucial. We hypothesized that electrical impedance tomography (EIT) reliably displays distribution of ventilation between left and right lung and may thus be used to verify correct DLT placement online. METHODS Regional ventilation was studied by EIT in 40 patients requ...

Lung inflammatory responses in the absence of infection are considered to be one of primary mechanisms of ventilator-induced lung injury. Here, we determined the role of calpain in the pathogenesis of lung inflammation attributable to mechanical ventilation. Male C57BL/6J mice were subjected to high (28 ml/kg) tidal volume ventilation for 2 h in the absence and presence of calpain inhibitor I (...

background extraperitoneal laparoscopy has become a common technique for many surgical procedures, especially for inguinal hernia surgery. investigations of physiological changes occurring during extraperitoneal carbon dioxide (co2) insufflation mostly focused on blood gas changes. to date, the impact of extraperitoneal co2 insufflation on respiratory mechanics remains unknown, whereas changes ...

BACKGROUND It is not well known what is the main mechanism causing lung heterogeneity in healthy lungs under mechanical ventilation. We aimed to investigate the mechanisms causing heterogeneity of regional ventilation and parenchymal densities in healthy lungs under anesthesia and mechanical ventilation. METHODS In a small animal model, synchrotron imaging was used to measure lung aeration an...

BACKGROUND Sustained inflations (SI) are used with the initiation of ventilation at birth to rapidly recruit functional residual capacity and may decrease lung injury and the need for mechanical ventilation in preterm infants. However, a 20 second SI in surfactant-deficient preterm lambs caused an acute phase injury response without decreasing lung injury from subsequent mechanical ventilation....

Background: The effect of intravenously administered dexmedetomidine on oxygenation during one-lung ventilation has not been studied. The hypothesis of this prospective, randomized study was that dexmedetomidine would be associated with an improvement in oxygenation during onelung ventilation. The secondary outcome was the change in the intrapulmonary shunt. Materials and Methods: Thirty patien...

As the population ages, the number of patients in whom lung disease develops and who require surgical intervention will continue to rise. When compared with open thoracotomy, video-assisted thoracoscopic surgery (VATS) offers patients significant advantages. Decreased invasiveness results in less blood loss, a lower rate of infection, and less postoperative pain and allows for quicker recovery....