Nausea and vomiting is a common and distressing postoperative complication with an incidence of 25-43% after both inpatient and day care surgery1. Patients rate freedom from postoperative nausea and vomiting (PONV) as their most IJBAR (2013) 04 (01) www.ssjournals.com Abstract Purpose: To compare the efficacy of ondansetron-dexamethasone combination with ondansetron alone for prevention of post...

Ondansetron is a 5-hydroxytryptamine receptor antagonist which is known to be a highly effective anti-emetic drug for chemotherapy-associated nausea and vomiting and for postoperative nausea. We report here a case where ondansetron was used in severe hyperemesis gravidarum to avoid parenteral nutrition. The drug was used intermittently in every trimester with no apparent adverse effects on moth...

BACKGROUND AND OBJECTIVES Prophylaxis of postoperative nausea and vomiting has been the subject of several studies. The objective of the present study was to compare anti-emetics, and their association, in the prevention of postoperative nausea and vomiting. METHODS Seventy patients, ASA I and II, underwent epidural block associated with general anesthesia for gynecologic surgeries. Patients ...

BACKGROUND Nausea and vomiting are common chief postoperative complaints. The clinical literature indicates that postoperative nausea and vomiting (PONV) is common after orthopedic surgery. This study examines the clinical therapeutic efficacy of Ondansetron injected intravenously before the end of shoulder arthroscopy as antiemetic prophylaxis to help reduce the incidence of PONV. METHODS Pa...

BACKGROUND & OBJECTIVES Delayed emesis with cisplatin is a significant problem, which is often poorly controlled with conventional antiemetics. There is a relative paucity of data on the control of delayed emesis and rather inconsistent results have been reported. The present study aimed to compare the efficacy and tolerability of ondansetron versus metoclopramide in dose related grades of cisp...

The current Tactical Combat Casualty Care (TCCC) Guidelines recommend parenteral promethazine as the single agent for the treatment of opioid-induced nausea and/or vomiting and give a secondary indication of “synergistic analgesic effect.” Promethazine, however, has a well-documented history of undesired side effects relating to impairment and dysregulation of the central and autonomic nervous ...

PURPOSE Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy ...

BACKGROUND Postoperative nausea and vomiting (PONV) is a common distressing experience in patients following laparoscopic surgeries. This study was aimed at comparing the efficacies of Ondansetron-Dexamethasone combination with each drug alone as a prophylaxis against PONV in patients after elective laparoscopic cholecystectomy done under general anaesthesia. MATERIALS AND METHODS Hundred and...

OBJECTIVE To assess the evidence for the safety and effectiveness of antiemetics on gastroenteritis-induced vomiting in children and adolescents. DESIGN Systematic review. DATA SOURCES The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE searched from 1980 to March 2012. METHODS Methods included comprehensive searches, data synthesis, meta-analysis and mixed treatment co...

to compare the efficacy of acupressure wrist bands, ondansetron, metoclopramide and placebo in the prevention of vomiting and nausea after strabismus surgery. two hundred patients, asa physical status i or ii, aged between 10 and 60 years, undergoing strabismus surgery in farabi hospital in 2007-2008 years, were included in this randomized, prospective, double-blind and placebo-controlled study...