نتایج جستجو برای: oncolytic viruses
تعداد نتایج: 102002 فیلتر نتایج به سال:
Oncolytic viruses are emerging as a potential new way of treating cancers. They are selectively replication-competent viruses that propagate only in actively dividing tumor cells but not in normal cells and, as a result, destroy the tumor cells by consequence of lytic infection. At least six different oncolytic herpes simplex viruses (oHSVs) have undergone clinical trials worldwide to date, and...
Oncolytic virotherapy (OV) is a cancer therapy utilizing lytic viruses that specifically target cells for elimination. In this relatively new therapy, two contradictory observations have been made. Some studies showed immune responses including activated natural killer (NK) post oncolytic viral infection increased the cell death, while others reported such initial diminished anti-tumor efficacy...
Oncolytic viruses (OV) promote anti-tumour responses through the initiation of immunogenic cancer cell death which activates host’s systemic immunity. We have previously shown that intravenously administered HSV1716 is an effective treatment for mammary cancer. However, intravenous administration a virus has potential to result in neutralization and sequestration may reduce efficacy. Here, we s...
Oncolytic viruses selectively target and replicate in cancer cells, providing us with a unique tool with which to target and kill tumour cells. These viruses come from a diverse range of viral families including reovirus type 3 Dearing (RT3D), a non-pathogenic human double-stranded RNA oncolytic virus, which has been shown to be an effective therapeutic agent, both as a mono-therapy and in comb...
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