BACKGROUND The aim of this pilot study was to test the feasibility of a bihormonal (glucagon and insulin) closed-loop (CL) system by challenging the system with two meals and 30 min exercise. METHODS Ten patients with type 1 diabetes treated with continuous subcutaneous insulin infusion underwent a standardized protocol on three different occasions: 40 g carbohydrate breakfast followed 2 h la...

PURPOSE Connective tissue pulleys inflect the extraocular muscles (EOMs) and receive insertions from some fibers. The authors investigated insertions and anatomic relationships of fiber fascicles within rectus EOMs to clarify the relationship to their pulleys. METHODS Two human and two monkey orbits were removed intact, serially sectioned in the coronal plane, histologically stained, and digi...

PURPOSE It was to test the validity and reliability of an online version of the Female Sexual Function Index (FSFI). METHODS An online version of the FSFI was compared to the pen and paper traditional version. Physiotherapy students in three cities were randomly allocated to two groups - G-pp/ol (n=126) and G-ol/pp (n=147). G-pp/ol women replied to th FSFI using the traditional pen and paper ...

The title compound, C(5)H(13)NO, is an aliphatic amino-alcohol with both functional groups residing on terminal C atoms. Apart from the hy-droxy group, all non-H atoms are nearly co-planar, the maximum deviation of an atom taking part in the least-squares plane defined by the mentioned non-H atoms being 0.029 (1) Å. In the crystal, O-H⋯N and N-H⋯O hydrogen bonds connect the mol-ecules, forming ...

In the essentially planar (r.m.s. deviation = 0.023 Å) title compound, C(10)H(6)Br(2)O, an intra-molecular O-H⋯Br hydrogen bond generates an S(5) ring. In the crystal, mol-ecules are linked by an ⋯O-H⋯O-H⋯O- C(2) chain extending along [100], which involves the same H atom that participates in the intra-molecular hydrogen bond. Aromatic π-π inter-actions [centroid-centroid separation = 3.737 (4)...

In the title compound, C(9)H(8)Br(2)O, the cyclo-pentene ring adopts an envelope conformation with the brominated C atom as the flap. In the crystal, mol-ecules are linked by strong O-H⋯O hydrogen bonds into zigzag C(4) chains along [010]. In addition, a C-H⋯π inter-action involving the benzene ring and the H atom attached to the hy-droxy-lated C atom is observed.

The mol-ecule of the title compound, C(9)H(5)Cl(2)NO, is essentially planar [give maximum or r.m.s. deviation] and the hydr-oxy group acts as a hydrogen-bond donor to the N atom of a symmetry-related mol-ecule, generating a hydrogen-bonded dimer,which lies on a twofold rotation axis.

The molecule of the title pyridine derivative, C(5)H(6)N(2)O, shows approximate C(s) symmetry. Intra-cyclic angles cover the range 118.34 (10)-123.11 (10)°. In the crystal, O-H⋯N, N-H⋯O and N-H⋯N hydrogen bonds connect the mol-ecules into double layers perpendicular to the a axis. The shortest centroid-centroid distance between two π-systems is 3.8887 (7) Å.

Adolescence is the critical time for developing proper oligodendrocyte (OL)-neuron interaction and the peak of onset for many cognitive diseases, among which anxiety disorders display the highest prevalence. However, whether impairment of de novo OL development causes neuronal abnormalities and contributes to the early onset of anxiety phenotype in childhood still remains unexplored. In this st...

The resistant cherry tomato (Solanum lycopersicum var. cerasiforme) line LC-95, derived from an accession collected in Ecuador, harbors a natural allele (ol-2) that confers broad-spectrum and recessively inherited resistance to powdery mildew (Oidium neolycopersici). As both the genetic and phytopathological characteristics of ol-2-mediated resistance are reminiscent of powdery mildew immunity ...