Giriş ve Amaç: Glioblastoma kötü prognozlu agrasif beyin tümörlerinden biridir glioblastoma için mevcut tedavi yöntemleri oldukça sınırlıdır. Sitokalasin B'nin (CB) kanser hücre hatları üzerinde inhibitör etki göstermektedir, ancak antikanser etkileri henüz tam olarak anlaşılamamıştır. Bu çalışmada, CB'nin U87 insan hücrelerinde nükleer faktör eritroid 2 ile ilişkili (Nrf2) sinyal yolağı üzerin...

Not only bile but also chronic cholecystitis may play a role in gallbladder carcinogenesis. Numerous studies have revealed a close correlation between chronic inflammation and neoplasia. The experiments were conducted on paraffin sections, obtained from 377 surgically resected gallbladders with chronic cholecystitis. Immunohistochemical reaction was conducted on deparaffinized sections, using a...

Selenite (SeL) or selenomethionine (SeM) are the most common selenium (Se) compounds taken as dietary antioxidants to reduce oxidative stress. Because the public may frequently supplement Se compounds at high doses, the possible pro-oxidant effect of Se becomes a concern. SeL and SeM have entirely different pharmacokinetic effects based on dose-related cytotoxicity. Our laboratory has shown pre...

Bu çalışmada resveratrolün (RES) metotreksat (MTX) uygulanan ratlarda lökosit yüzdelerine, total oksidan (TOS)-antioksidan durumuna (TAS) ve DNA hasarına (8-OHdG) etkisi araştırıldı. Çalışmada kullanılan ratlar rastgele her biri 10 rattan oluşan 4 gruba ayrıldı. Gruplar, kontrol grubu, MTX grubu (20 mg/kg i.p., haftada 1 kez, iki hafta), RES (40 mg/kg/gün oral, 14 gün) MTX+RES i.p, hafta 40 ola...

The aim of this study is to determine the changes in serum levels malondialdehyde and 8-hydroxy-2'-deoxyguanosine, as indicators oxidative stress, response periodontal treatment adyuvanted with topical doxycycline. Methods: Thirty four patients disease were studied (DOX group n=16; Control n=18), determining 8-hydroxy-2'-deoxyguanosine urine at baseline three months after non-surgical treatment...

Background: Several aspects of chronic kidney disease (CKD) such as the incidence rate and mortality are concerning. Oxidative stress contributes to progression in patients with CKD; however, a specific correlation between several markers oxidative estimated glomerular filtration (eGFR) albumin-creatinine ratio (ACR) Indonesian population has not been sufficiently de...

Eight-hydroxyguanosine (8-OHdG) is considered as one of the principle forms oxygen radicals that stimulated oxidative stress and has been extensively utilized a biomarker for oncogenesis. The primary goal present study was to investigate alteration in levels 8-OHdG, antioxidant profile proinflammatory cytokines patients with lung carcinoma. Blood samples were collected from 40 cases cancer (sta...

The usefulness of urinary hydrogen peroxide (H(2)O(2)) as an oxidative stress biomarker was evaluated in 766 healthy Japanese. The mean level of urinary concentrations of H(2)O(2) was 5.66 ± 8.27 μmol/g creatinine, and was significantly higher in females than in males. Significant correlations of H(2)O(2) were observed with age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), ...