today’s knowledge on oesophageal adenocarcinoma and its rising incidence has encouraged researcher to illustrate relationship between barrett’s disease and progression to adenocarcinoma. the incidence of this disease has been accelerated sharply in current decades since people life has changed. studies have been demonstrated that several potential factors including genetical  and environmental ...

Tylosis (hyperkeratosis palmaris et plantaris) is characterised by focal thickening of the skin of the hands and feet and is associated with a very high lifetime risk of developing squamous cell carcinoma of the oesophagus. This risk has been calculated to be 95% at the age of 65 in one large family, however the frequency of the disorder in the general population is not known and is likely to b...

BACKGROUND In a previous meta-analysis, we identified a survival benefit from neoadjuvant chemotherapy or chemoradiotherapy before surgery in patients with resectable oesophageal carcinoma. We updated this meta-analysis with results from new or updated randomised trials presented in the past 3 years. We also compared the benefits of preoperative neoadjuvant chemotherapy compared with neoadjuvan...

Human papillomavirus (HPV) may have a pathogenic role in squamous cell carcinoma of the oesophagus. Tylosis, an inherited thickening of the skin of the palms and soles, was associated with a high risk of developing squamous cell carcinoma of the oesophagus among members of a large family in Liverpool. The resected carcinomas of the oesophagus was examined from four such patients with DNA probes...

OBJECTIVE Lymph node metastasis is a characteristic of malignant cancers and is observed more frequently in oesophageal cancer than in other digestive tract cancers, making it one of the most important prognostic factors. Vascular endothelial growth factors C (VEGF-C) and D (VEGF-D) are important lymphangiogenic factors in human cancers and lymphangiogenesis is associated with lymph node metast...

Carcinoma of the oesophagus is a relatively uncommon malignancy in the United Kingdom, with a mean incidence of approximately 7.5 per 100,000 population. However, this translates into some 4,000 deaths per annum, and management of oesophageal cancer presents a major therapeutic challenge. The reasons for this are the magnitude of surgery involved in resection of oesophageal tumours, and the poo...

Using a panel of carcinoembryonic antigen (CEA) related antibodies in normal oesophageal squamous mucosa CEA expression is present on suprabasal squames localised to the cell membrane. Immunoblotting shows that this positivity is predominantly due to a glycoprotein of around 180 kDa representing CEA itself. Positivity in squamous carcinomas is confined to cells in foci of squamous differentiati...

A 39 year old woman was admitted to hospital with increasing breathlessness and cough productive of green sputum over 3 months. An oesophageal carcinoma had been resected 3 years previously and she had received prophylactic radiotherapy to the thorax post-operatively. At follow-up failure to gain weight had caused concern but there had been no evidence of tumour recurrence or metastasis. Episod...

A series of 237 cases of oesophageal carcinoma admitted to two thoracic units in Ceylon is analysed.Evidence suggestive of an aetiological link between betel chewing and high incidence of the tumour in Ceylon is presented. The sex incidence is unusual in that there is a preponderance of females in the series. A significant proportion of patients were women under 40 years of age. The middle thir...