This clinical report describes the delayed development of a maxillary second premolar. The premolar developed when the patient was between the ages of 12 and 16 years. The development of the tooth was discovered from a panoramic radiograph taken when the patient was 17 years, 1 month of age. Previous to this discovery, the tooth had been diagnosed as congenitally missing. The transition from th...

Loss- and gain-of function approaches modulating canonical Wnt/β-catenin activity have established a role for the Wnt/β-catenin pathway during tooth development. Here we show that Wnt/β-catenin signaling is required in the dental mesenchyme for normal incisor development, as locally restricted genetic inactivation of β-catenin results in a splitting of the incisor placode, giving rise to two in...

In an earlier radiographic study of dental development in the third-trimester fetus, considerable variability was obsersed in the degree of rotation of the deciduous lateral incisors (VAN DER LINDEN, MACNAMARA and Buxi, J Dent Res 51: 71, 1972) Accordingly, we became interestedl in the extent of lateral-incisor rotation in still younger specimens, the age at onset of lateralincisor rotation, an...

This paper aims at quantifying ontogenetic differences between bonobo (Pan paniscus) and chimpanzee (Pan troglodytes) endocrania, using dental development as a timeline. We utilize a methodology based on smooth and invertible deformations combined with a metric of "currents" that defines a distance between endocranial surfaces and does not rely on correspondence between landmarks. This allows u...

TGF-β/BMPs have widely recognized roles in mammalian development, including in bone and tooth formation. To define the functional relevance of the autonomous requirement for TGF-β signaling in mouse tooth development, we analyzed osteocalcin-Cre mediated Tgfbr2 (OC(Cre)Tgfbr2(fl/fl)) conditional knockout mice, which lacks functional TGF-β receptor II (TβRII) in differentiating cementoblasts and...

Enamel prism-packing patterns reflect the past history of ameloblasts, providing information about growth patterns in tooth development. Here, the area and density of enamel prisms on the cuspal surface of molar teeth were measured to examine if the onset and rate of enamel apposition differ according to stage of development and/or cusp type. Scanning electron-microscopic images were taken from...

In a cross-sectional study, data from records of cattle slaughtered over a 1-year period at a large abattoir in South West England were analysed using an ordered category response model to investigate the inter-relationships between age, sex and breed on development of the permanent anterior (PA) teeth. Using the model, transition points at which there was a 50% probability of membership of eac...

In postnatal dental development, and in crown size itself, there is a demonstrable "distance gradient" so that teeth closer together within a jaw quadrant show higher correlations. Thus, adjacent teeth exhibit systematically higher commonality in both tooth formation and crown size than more remote teeth in the same quadrant, despite absolute differences in formation (calcification, root elonga...

Equine dental developmental abnormalities can involve tooth number, morphology, or position in the dental arcades. Abnormalities of dental development and eruption occur quite commonly in the horse and result in a wide range of clinical conditions. Some developmental dental abnormalities of a young horse may not cause the animal to exhibit clinical signs of dental disease until it reaches middl...