and it is with very great pleasure that we welcome his latest publication. Nearly half the book is devoted to the enamelThe author is to be congratulated on being the first to describe the minute anatomy of this structure in the elephant. He confirms Smreker's views with regard to the enamel prisms, that they are not rounded or polygonal in transverse section, but have an arched form owing to t...

The continuously growing rodent incisor is a widely used model to investigate odontogenesis and mineralized tissue formation. This study focused on evaluating the mouse mandibular incisor as an experimental biological tool for analyzing in vivo the capacity of odontoblast-like progenitors or bioactive molecules to contribute to reparative dentinogenesis. We describe here a surgical procedure al...

The aim of the present work was to characterize the odontoblastic proliferation, differentiation, and matrix mineralization in culture of the recently established M2H4 rat cell line. Proliferation was assessed by cell counts, differentiation by RT-PCR analysis, and mineralization by alizarin red staining, atomic absorption spectrometry, and FTIR microspectroscopy. The results showed that M2H4 c...

Primary cilium is a protruding cellular organelle that has various physiological functions, especially in sensory reception. While an avalanche of reports on primary cilia have been published, the function dental cells remains to be investigated. In this study, we focused dentin-producing odontoblasts. Odontoblasts, like most other cell types, possess cilia, which disappear upon knockdown intra...

The objectives of our study were to investigate the roles mTORC1 in odontoblast proliferation and mineralization determine mechanism by which regulates mineralization. In vitro, MDPC23 cells treated with rapamycin (10 nmol/L) transfected a lentivirus for short hairpin (shRNA)-mediated silencing tuberous sclerosis complex (shTSC1) inhibit activate mTORC1, respectively. CCK8 assays, flow cytometr...