This issue contains a wide variety of articles covering new genes and mutations, unusual phenotypes, and a reminder that novel genetic technologies need to be paired with the appropriate mechanisms to inform patients of new results or annotations of DNA variants.

Clark, Raymond J., and Kenneth J. Rodnick. Pressure and volume overloads are associated with ventricular hypertrophy in male rainbow trout. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R938–R946, 1999.—We investigated whether ventricular hypertrophy in reproductively mature male trout (Oncorhynchus mykiss) is associated with elevated hemodynamic loads. We measured ventral aor...

Kinoshita, Mine, Eisuke Kume, Shigeki Igarashi, Nobuko Saito, and Hiroshi Narita. Role of salivary mucin in the protection of rat esophageal mucosa from acid and pepsin-induced injury. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G796–G800, 1999.—The mucosal defensive mechanisms of the esophagus against acid and pepsin remain to be elucidated. In the present study, we investigated the...

Wade, Gregory R., Lisanne G. Laurier, Harold G. Preiksaitis, and Stephen M. Sims. Delayed rectifier and Ca21-dependent K1 currents in human esophagus: roles in regulating muscle contraction. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G885–G895, 1999.—We have examined K1 channels and their function in human esophageal smooth muscle using perforated patch recording, RT-PCR to identify...

Schwartz, Gary J., Andrew Whitney, Chris Skoglund, Thomas W. Castonguay and Timothy H. Moran. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-Areceptors. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1144– R1151, 1999.—Adult Otsuka Long-Evans Tokushima fatty (OLETF) rats lack functional cholecystokinin A (CCK-A) receptors, are dia...

temperature within a very narrow temperature range. Therefore, when body temperature rises above its normally regulated range, because of either environmental factors or excess metabolic heat production, irreversible thermoregulatory failure may rapidly develop. Operating at a very “high gain,” the thermoregulatory system works in concert with a set of coded behavioral functions to prevent/atte...

Ahrén, Bo, and Peter J. Havel. Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells). Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R959–R966, 1999.—The effect of leptin on insulin secretion is controversial due to conflicting results in the literature. In the present study, we incubated insulinproducing rat insulinoma INS-1 cells...

Background: Fasciola hepatica is a helminth parasite of global importance in livestock, with major economic impact. However information on F. hepatica infections in Irish pasture-based dairy herds is limited. Therefore this study was conducted in order to determine the prevalence, seasonality and management factors associated with F. hepatica. A total of 319 Irish dairy herds were selected for ...

Wang, Jinjuan, and James C. Rose. Developmental changes in renal renin mRNA half-life and responses to stimulation in fetal lambs. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1130–R1135, 1999.—In the perinatal period there is increased renin gene expression in the kidney compared with other stages of development. This may be related to changes in responsiveness of the renin...

Hsieh, Po-Shiuan, Mary Courtney Moore, Bess Marshall, Michael J. Pagliassotti, Brian Shay, Dennis Szurkus, Doss W. Neal, and Alan D. Cherrington. The head arterial glucose level is not the reference site for generation of the portal signal in conscious dogs. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E678–E684, 1999.— Experiments were performed on twelve 42-h-fasted, conscious dogs to determi...