We investigated the mechanism of action of metabolically stable lysophospholipid analogues (LPAs), with potent anti-tumour and anti-protozoal activity against Trypanosoma cruzi, the causative agent of Chagas' disease. Against the axenically grown epimastigote form of the parasite, the IC(50)s after 120 h for ET-18-OCH(3), miltefosine and ilmofosine were 3, 1 and 3 microM, respectively; at highe...

The main aim of this thesis was to study domestication effects on foraging behaviour in chickens and to investigate whether and how domestication and selection for high production have influenced adaptability in chickens. Two domestic strains of chickens (egg layers and meat type chickens) and their wild ancestor, the red jungle fowl (RJF) were compared in different test situations with respect...

Fakultetsopponent: Biträdande professor Simon Matti, institutionen för ekonomi, teknik och samhälle, avdelningen för samhällsvetenskap vid Luleå tekniska universitet.

Due to the need for advanced computer-controlled functionality in distributed embedded systems the requirements on network communication are becoming overly intricate. This dissertation targets the requirements that are concerned with real-time guarantees, run-time adaptation, resource utilization and flexibility during the development. The Flexible Time-Triggered Switched Ethernet (FTT-SE) and...

Traumatic brain injuries (TBI) are receiving increasing attention due to a combination of injuries related to war and sports, as well as to an increasing number of traffic accident survivors. Today the leading cause of death in young adults in industrialized nations is traumatic brain injury and in the population under 35 years, the death rate is 3.5 times that of cancer and heart disease combi...

Metric interval temporal logic (MITL) provides a tool to formulate high level tasks in an easy way. This allows to specify behaviour of a dynamical system in a given environment which lies beyond the scope of simple stabilization. Finding an input of the system which satisfies the MITL formula, demands new techniques and algorithms. In this thesis, a novel approach is presented which abstracts ...

Activation of Natural Killer-like T cells (NKT) with the CD1d ligand α-GC leads to enhanced production of anthrax toxin protective Ag (PA)-neutralizing Abs, yet the underlying mechanism for this adjuvant effect is not known. In the current study we examined the role of Th1 and Th2 type responses in NKT-mediated enhancement of antibody responses to PA. First, the contribution of IL-4 and IFNγ to...

Here, we report improved solubility and enhanced colonic delivery of reduced bromonoscapine (Red-Br-Nos), a cyclic ether brominated analogue of noscapine, upon encapsulation of its cyclodextrin (CD) complexes in bioresponsive guar gum microspheres (GGM). Phase-solubility analysis suggested that Red-Br-Nos complexed with β-CD and methyl-β-CD in a 1:1 stoichiometry, with a stability constant (Kc)...

................................................................................................1 Populärvetenskaplig sammanfattning................................................3 Ett Norovirus Pusselstudier på humana och bovina norovirus och deras koppling till individers mottaglighet för sjukdom .................................. .3 Abbreviations................................................

First principles calculations are usually concerned with properties calculated at temperature 0 K. However, the industrially important materials are functioning at finite temperatures. To fill such a gap a first-principles based modeling of free energy has been developed in this thesis and finite temperature properties of different phases of Fe and Mn have been calculated and contrasted with av...