OBJECTIVE Current endovascular technology does not offer a perfect solution for all cerebral aneurysms. Our group has built two versions of a novel aneurysm intrasaccular occlusion device (AIOD) to address the drawbacks associated with current occlusion devices. The objective of the present study was to perform pilot proof of concept in vivo testing of this new AIOD in swine and canines. METH...

Early reperfusion after a coronary occlusion may reduce myocardial infarct size, but late reperfusion into necrotic myocardium may alter post-infarction healing. In rabbits, we compared 1- or 3-week-old scars resulting from permanent coronary occlusion to those resulting from a 1- or 3-hour occlusion followed by reperfusion. Reperfusion at 1 hour post-occlusion did not affect scar mechanical pr...

In a retrospective study, ultrasonic Doppler findings obtained with directional continuous wave equipment were evaluated in 51 patients in whom subsequently the diagnosis of an internal carotid artery occlusion was confirmed by angiography or autopsy. The evaluation was based on the registration of mean velocity analogues of medial frontal (supratrochlear) and common carotid artery blood flow. ...

Tumor cell extravasation into the brain requires passage through the blood-brain barrier (BBB). There is evidence that exercise can alter the oxidation status of the brain microvasculature and protect against tumor cell invasion into the brain, although the mechanisms are not well understood. In the current study, we focused on the role of microenvironment generated by exercise and metastasizin...

While the behavioral and physiologic effects of an early period of monocular deprivation can be extremely severe, they are not necessarily irreversible. Considerable recovery can occur if visual input is restored to the deprived eye sufficiently early, particularly if the nondeprived eye is occluded at the same time (reverse occlusion). This study examines the permanence of the visual recovery ...

Mortality following permanent occlusion of both common carotid arteries decreases as the time between the first and second occlusions increases in Fischer 344 rats. Our goal was to examine the possibility that collaterals develop after unilateral carotid artery occlusion. During temporary occlusion of both carotid arteries in nine ketamine-anesthetized male rats, mean +/- SEM blood flow in both...

When using invasive methods to measure hemodynamic parameters in rodents, most researchers studying chronic myocardial infarct are using permanent suture-induced descending coronary artery occlusion. Usually, they perform the Pressure-Volume (PV) Catheter study at 4 weeks (28 days) post-MI (3, 4, 8). Some researchers extend the artery occlusion study time another 2 weeks (1, 2) to study the eff...

Littermate gilts were used to study the effects of exercise during the growing-finishing period on performance, age at puberty and conception rate. In trial 1, 12 gilts walked 15 min daily on a treadmill 6 d/wk (Monday through Saturday) until they attained body weights of about 100 kg, while 12 littermate gilts were not forced to exercise. Initial weight and age averaged 24.7 kg and 74 d, respe...

I. The effects of varying levels of physical activity were tested in rats, starting at ages of 21, 32 and 55 days and continuing until go, 100, 125 and 205 days. 2. Weight changes did not differ significantly between the exercise groups, except in the groups tested up to zog days, when both the exercised group and the group with limited activity were significantly lighter than the control group...