Currently, there is no effective therapy for high grade gliomas. 8-Methoxypsoralen (8-MOP) is a compound used in the treatment of skin diseases combined with UV light irradiation. In this work, rat glioma C6 cells, normal astrocytes and human glioblastoma GL-15 cells comprised an in vitro model to evaluate the antitumor activity of 8-MOP. We found that 8-MOP promoted a time- and concentration-d...

Spore formation in Saccharomyces cerevisiae is driven by de novo assembly of new membranes termed prospore membranes. A vesicle-docking complex called the meiosis II outer plaque (MOP) forms on the cytoplasmic faces of the spindle-pole bodies at the onset of meiosis II and serves as the initiation site for membrane formation. In this study, a fluorescence-recovery assay was used to demonstrate ...

strategic programming, complex supply chain, lean, production programming, suppliers selection,   electre this paper represents a model of strategic programming with limited resources in a complex supply chain. the main goal of the proposed model is to increase efficiency and effectiveness of the supply chain with respect to income increases and cost decreases. using special objective functions...

nowadays, the necessity of accurate quantitative decision support methods is becoming a critical subject for managers as rivalry between organizations caused a more fragile economic environment and brand reputation is becoming more important. furthermore, dealing with incidents after they happened is not accepted by customers anymore. managers require powerful decision making tools to support t...

In this work, a novel agent-based day-ahead power management scheme is proposed for multiple-microgrid distribution systems with the intent of reducing operational costs and improving system resilience. The sharing algorithm executes within each microgrid (MG) locally, neighboring MGs cooperate via multi-agent cooperation scheme, established to model communication among agents. agent modeled as...

An odorant-binding protein from the Southern house mosquito, Culex pipiens quinquefasciatus (Cqui-OBP1) binds to the mosquito oviposition pheromone (MOP), 6-acetoxy-5-hexadecanolide to facilitate the transport of MOP to membrane-bound odorant receptors. We report complete NMR chemical shift assignments of Cqui-OBP1 bound to the MOP pheromone obtained at pH 7.0 and 25 degrees C (BMRB no. 16175).

Nociceptin/orphanin FQ peptide receptor (NOP) agonists produce antinociceptive effects in animal models after spinal administration and potentiate μ-opioid receptor (MOP)-mediated antinociception. This study determined the antinociceptive effects of spinally administered bifunctional NOP/MOP ligands and the antinociceptive functions of spinal NOP and MOP receptors in mice. Antinociceptive effec...

7-Methylguanine was found in hydrolysates of liver and pancreas DNA from Syrian golden hamsters given a single dose of N-[1-14C]nitrosobis(2-oxopropyl)amine (BOP). This led us to examine the carcinogenicity of a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine (MOP). MOP was found to be a potent pancreatic carcinogen by either single or weekly s.c. injections. A single...

The use of metalevel architectures for the implementation of fault-tolerant systems is today very appealing. Nevertheless, all such fault-tolerant systems have used a general-purpose metaobject protocol (MOP) or are based on restricted reflective features of some object-oriented language. According to our past experience, we define in this paper a suitable metaobject protocol, called FT-MOP for...