Lipid peroxidation is considered to be an important mechanism of leaf senescence. The peroxidation of lipids can be initiated by free radicals. H 2 O 2 itself is active oxygen species and can react with superoxide radicals to form more reactive hydroxyl radicals in the presence of trace amounts of Fe or Cu. Thus, it is of interest to investigate the relationship between lipid peroxidation and H...

Thiourea is the parent compound of a group of compounds known t.o have goitrogenic activity. These substances prevent the formation of organically bound iodine from iodide ion (l-6), but the mechanism of this action is unknown. ‘Paper I of this series (7) showed that when thiourea labeled with radioactive sulfur was administered to rats the concentration of radioactivity in the thyroid gland 24...

Deuterium isotope effects were evaluated as a strategy to optimize the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole (NVS-CRF38), a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist. In an attempt to suppress O-demethylation of NVS-CRF38 without losing activity against the CRF1 receptor, the protons at ...

Arvanil, a structural "hybrid" between the endogenous cannabinoid CB1 receptor ligand anandamide and capsaicin, is a potent agonist for the capsaicin receptor VR1 (vanilloid receptor type 1), inhibits the anandamide membrane transporter (AMT), and induces cannabimimetic responses in mice. Novel arvanil derivatives prepared by N-methylation, replacement of the amide with urea and thiourea moieti...

Facilitated SO4(2-) transfers by hydrogen bond-forming ionophores are investigated across the nitrobenzene (NB)-water interface by using polarography with a dropping electrolyte electrode. Bis-thiourea 1, alpha,alpha'-bis(N'-p-nitrophenylthioureylene)-m-xylene, is found to significantly facilitate the transfer of the highly hydrophilic SO4(2-) whereas its counterpart, N-(p-nitrophenyl)-N'-propy...

We assessed in this work how a chemical structure difference could influence a supramolecular organization and then its biological properties. In our case study, we considered two amphiphilic lipidic gene vectors. The chemical difference was situated on their hydrophilic part which was either a pure neutral thiourea head or a mixture of three thiourea function derivatives, thiourea, iminothiol,...

With the notable exceptions of water, ammonia and a very limited number of other examples, there have been relatively few highpressure structural studies of simple molecular compounds. Such studies can provide fascinating information about intermolecular interactions and pressure-induced phase transition, in particular hydrogen-bonding interactions. Recent results for thiourea and urea obtained...

l-Glutamate uptake, thiourea uptake, and methylammonium uptake and the intracellular ammonium concentration were measured in wild-type and mutant cells of Aspergillus nidulans held in various concentrations of ammonium and urea. The levels of l-glutamate uptake, thiourea uptake, nitrate reductase, and hypoxanthine dehydrogenase activity are determined by the extracellular ammonium concentration...