نتایج جستجو برای: nucleotide 5 monophosphates

تعداد نتایج: 1321276  

Journal: :Nucleic acids research. Supplement 2002
Takeshi Wada Tomomi Shimazaki Shingo Nakagawa Takashi Otuki Shinya Kurata Tsutomu Suzuki Kimitsuna Watanabe Kazuhiko Saigo

Recently, novel taurine-containing uridine derivatives were discovered in mammalian mitochondrial tRNAs, and these modified ribonucleosides existed at the first position of the anti-codon. This paper describes the chemical synthesis of these novel uridine derivatives, 5-taurinomethyluridine (tau m5U) and 5-taurinomethyl-2-thiouridine (tau m5s2U). These taurine-containing uridine derivatives wer...

2010
L.A. Alexandrova E.R. Shmalenyuk S.N. Kochetkov V.V. Erokhin T.G. Smirnova S.N. Andreevskaia L.N. Chernousova

The WHO has declared tuberculosis (TB) a global health emergency. Therefore, there is an urgent need to discover and develop new anti-TB drugs. Here we report on a new category of 5-substituted pyrimidine nucleosides as potent inhibitors of Myco-bacterium tuberculosis growth in vitro. A series of 2'-deoxy-, 3'-azido-2',3'-dideoxy-, and 3'-amino-2',3'-dideoxypyrimidine nucleoside analogues beari...

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