Catalytic activity of a series of potent amideand amine-based organoselenium compounds are studied in the presence of various aromatic thiols having electron donating and electron withdrawing substituents on the phenyl ring. This study suggests that the antioxidant activities of the synthetic GPx mimics can be significantly increased by the incorporation of a suitable electron donating group on...

Methacrolein (MAL) is an important intermediate extensively used in the manufacture of methyl methacrylate and other materials (polymers resins). In this study, a series secondary amines/acids were explored as catalysts for condensation formaldehyde propionaldehyde to prepare MAL. It was found that structure amines acids directly affected yield The effect catalyst closely related nucleophilicit...

The carbapenem class of ?-lactams has been optimized against Gram-negative bacteria producing extended-spectrum ?-lactamases by introducing substituents at position C2. Carbapenems are currently investigated for the treatment tuberculosis as these drugs potent covalent inhibitors l,d-transpeptidases involved in mycobacterial cell wall assembly. optimization carbapenems inactivation unusual targ...

Nitrate Ion-Separation The underlying prerequisite for materials design to achieve on-target separation of low nucleophilic nitrate ions has been unclear. By fabricating cation-ordered layered double hydroxides (LDHs) via topochemical reaction, in article number 2201484, Tomohito Sudare, Katsuya Teshima, and colleagues demonstrate that the hexagonal arrangement effectively facilitates a stable ...

Sulfoximines are an interesting class of compounds, which exhibit Brønsted and Lewis basicity, nucleophilicity, C−H acidity, N−H hydrogen-bond acceptor capability chirality. have received renewed interest in recent times, since incorporation a sulfoximine group can provide drug candidates with favorable properties. The synthesis N−H, α-C−H o-C−H functionalization sulfoximines currently topics c...

Two subvalent, redox-active diborane(4) anions, [3]4? and [3]2?, carrying exceptionally high negative charge densities are reported: Reduction of 9-methoxy-9-borafluorene with Li granules without stirring leads to the crystallization B(sp3)?B(sp2) diborane(5) anion salt Li[5]. [5]? contains a 2,2?-biphenyldiyl-bridged B?B core, chelating 2,2?-biphenyldiyl moiety, MeO substituent. Li[5] Na metal...