PURPOSE To assess, in an in vitro model of acute hematoma, whether hemoglobin immobilization by clot and red cell membrane aging can account for the T2 shortening usually attributed to deoxyhemoglobin. METHODS Clotted and heparinized blood samples were packed (100% hematocrit). The apparent magnetization transfer rate (AMTR), T1 and T2 relaxation rates of the samples, and images with a volunt...

Abstract Melittin, the most potent pharmacological ingredient of honey bee venom, induces haemolysis, lymphocyte lysis, long-term pain, localised inflammation, and hyperalgesia. In this study, efforts were made to subdue melittin’s ill effects using a chaperone peptide called ‘mini-αA-crystallin’ (MAC) derived from eye lens αA-crystallin. Haemolytic test on human red blood cells, percentage via...

p ATIENTS with acquired auto-immune hemolytic anemia associated with a decreased red cell production have been reported by several authors.1-5 We have observed such cases among patients with acquired auto-immune hemolytic anemia due to incomplete antibodies of the warm variety. There have been many reports6 ’ suggesting the sensitization and damages of erythroblasts in the bone marrow by anti-e...

The buffy coat in a haematocrit tube consists of white cells, which, in spite of their larger size, fall with less velocity than the smaller red cells. This consideration suggested that the bigger, nucleated red cells might be found in increased numbers in or immediately beneath the white cell layer, and this has proved to be the case. Incidentally, both macrocytes and microcytes are found conc...