An automatic method for estimating the density of cell nuclei in whole slide images (WSI's) of hepatic histological sections is presented. The method can be applied to hematoxylin-eosin (H&E) stained sections with slight histological atypism, such as early well-differentiated hepatocellular carcinoma (ewHCC). It is shown that measured nuclear density is affected by the nuclear size due to fragm...

The nuclear transfer process is one of the critical rate-limiting processes in transgene expression. In the present study, we report on the effect of compaction and the size of the DNA molecule on nuclear transfer efficiency by microinjection. A DNA/protamine complex- or variously-sized naked DNA molecules were injected into the cytoplasm or nucleus of synchronized HeLa cells. To evaluate the n...

background: the earlier atomic bomb explosion in hiroshima and nagasaki, and three worth mentioning nuclear accidents - detonation at fukushima daiichi nuclear plant, chernobyl nuclear fallout and an accident at three mile island nuclear power plant have made us more worried about the secure exploitation of nuclear energy. the central focus of this paper is to review radiation-mediated health e...

Parity and time invariance violating (P, T-odd) nuclear forces produce P, T-odd nuclear moments. In turn, these moments can induce electric dipole moments (EDMs) in atoms through the mixing of electron wavefunctions of opposite parity. The nuclear EDM is screened by atomic electrons. The EDM of an atom with closed electron subshells is induced by the nuclear Schiff moment. Previously the intera...

conclusion osem3d may provide better image quality and higher contrast than other methods for small animal imaging with the new myocardial imaging agent, [18f] fptp. results the location and size of myocardial infarction on pet images correlated closely with that observed with ttc staining. among the four reconstruction methods, osem3d provided the best assessment of infarct size (r2 = 0.994, p...

Myocardial perfusion SPECT is one of the most common imaging techniques performed in nuclear medicine departments. To avoid misleading interpretation, it is necessary to address the quality control and technical problems. The truncation artifact occurs when the patient size is large relative to the field of view of the camera, causing false perfusion defects in the LV myocardium, misinterpreted...

Geometrical structure, nuclear magnetic resonance (N1,1It) chemical shielding tensors, and chemical shiftsof silicon and carbon nucler are investigated for twn infinite size zigzag and armchair single-walled siliconcarbide nanotabes (SiCNTs). Geometrical structures of SieNTs, Sit bonds and bond angles of St and Cvertices in both zigzag and armchair nanotubes, Indicate that bond lengths are appr...

background: cataract extraction surgery remains the most commonly performed eye surgery by ophthalmologists. the maintenance of mydriasis is required throughout surgery to allow better visualization of the surgical field and a greater working space within the center of the eye. non-steroidal anti-inflammatory agents (nsaids) have their effect in maintaining mydriasis by their ability to inhibit...

Efficient delivery to the cell nucleus remains a significant challenge for many biomolecules, including anticancer drugs, proteins and DNAs. Despite numerous attempts to improve nuclear import including the use of nuclear localization signal (NLS) peptides and nanoparticle carriers, they are limited by the nanoparticle size, conjugation method, dependence on the functional nuclear import and in...