*Correspondence to: Clifford P. Brangwynne; Email: cbrangwy@princeton.edu Anomalies in the three-dimensional shape of the nucleus are associated with a number of genetic diseases. These shape distortions include lobulated structures, with localized bulges referred to as nuclear blebs. Blebbing can result from mutations in genes encoding lamin intermediate filaments that form the lamin cortex, a...

The aim of this study was to determine the extent of DNA fragmentation and the presence of denatured single-strand or normal double-strand DNA in spermatozoa with extruded nuclear chromatin (ENC) selected by high magnification. Fresh semen samples from 55 patients were prepared by discontinuous isolate concentration gradient. Spermatozoa with normal nucleus (NN) and ENC were selected at 8400× m...

We investigate the effects of nuclear quadrupole and hexadecapole couplings on the average angular momentum in sub-barrier fusion reactions. This quantity could provide a probe for nuclear shapes, distinguishing between prolate vs. oblate quadrupole and positive vs. negative hexadecapole couplings. We describe the data in the O + Sm system and discuss heavier systems where shape effects become ...

Nuclei exhibit quantum phase transitions (earlier called ground state phase transitions) between different shapes as the number of nucleons is modified, resulting in changes in the ground and low lying nuclear states. Special solutions of the Bohr Hamiltonian appropriate for the critical point of such shape phase transitions, as well as other special solutions applicable to relevant nuclear reg...

The 'amitotic' division of the macronucleus during binary fission in P. tetraurelia includes a detailed sequence of shape changes that are temporally coordinated with the adoption of a series of well-defined positions and orientations inside the cell. The deployment of nucleoplasmic microtubules that is spatially correlated with the shaping ritual is more complex and precise than has been repor...

Alterations in nuclear shape and positioning are often associated with changes in the behavior of cells (Starr and Fridolfsson, 2010). Recent studies proposed that tissue stiffness affects the levels of the nuclear lamina protein lamin A/C, resulting in altered transcriptional regulation (Simon and Wilson, 2011; Burke and Stewart, 2013; Zwerger et al., 2013; Fedorchak et al., 2014; Swift and Di...

We analyze formation of grand-design two-arm spiral structure in the nuclear regions of disk galaxies. Such morphology has been recently detected in a number of objects using high-resolution near-infrared observations. Motivated by the observed (1) continuity between the nuclear and kpc-scale spiral structures, and by (2) low arm-interarm contrast, we apply the density wave theory to explain th...