Three simple sensitive and reproducible visible spectrophotometric methods (A, B, and C) for the determination of Naratriptan hydrochloride (NTP) in bulk samples and pharmaceutical formulations are described. Method A is based on the formation of colored co-ordination complex with cobalt thiocyanate (CTC). Method B is based on the formation of colored species with citric acid acetic anhydride (...

Space-time paths and prisms are time geographic concepts delimiting the actual and potential mobility pattern of an object in space and time, respectively. While there is a range of similarity measures for space-time paths, it is only recently that researchers started to develop similarity measures for the space-time prism (STP). This paper proposes a new methodology for measuring the similarit...

program prior to designing and conducting toxicology studies. The purpose of the research concept document is to outline the general elements of a research program that would address the specific public health concerns that prompted the nomination of the substance or issue for study. It may also encompass substance-specific studies that address larger public health issues or topics in toxicolog...

OBJECTIVE To compare processes and outcomes of four public-private mix (PPM) projects on DOTS implementation for tuberculosis (TB) control in New Delhi, India; Ho Chi Minh City, Viet Nam; Nairobi, Kenya; and Pune, India. METHODS Cross-project analysis of secondary data from separate project evaluations was used. Differences among PPM project sites in impact on TB control (change in case detec...

The blood oxygen affinity of vertebrates is regulated, in part, through changes in red cell phosphate levels and increased oxygen affinity during reductions in inspired oxygen and is a well-described and common feature. However, during anaemia, when oxygen delivery is compromised by a reduction in blood oxygen carrying capacity, a lowering of blood oxygen affinity will facilitate oxygen unloadi...

The National Toxicology Program (NTP) dose-ranging studies typically employ five dosages and a concurrent control and are conducted for 2- and 13-week exposure periods. Because five doses are employed it suggested the possibilities of the occurrence of sub-NOAEL doses in many of these bioassays and of evaluating the occurrence of hormesis within the NTP bioassay. As a result, 59 environmentally...

Navy systems are inherently real-time. As these systems evolve with the introduction of new requirements, technologies, and commercial-off-theshelf (COTS) equipment, they are evolving toward more distributed systems. A key component to the deployment of real-time distributed systems in Navy applications is quality clock synchronization among the various computing platforms in the distributed sy...

Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome replication and transcription. We previously reported several structural states of the poliovirus RdRP nucleotide addition cycle (NAC) that revealed a unique palm domain-based active site closure mechanism and proposed a six-state NAC model including a hypothetical state representing translocation intermediates. Us...

This paper describes a recently designed system that measures the time transmitted by network time protocol (NTP) servers located in North, Central, and South America. Direct measurements of the time transmitted by each server are obtained by comparing the received time stamps to the Cordinated Universal Time scale, UTC(NIST), located at the National Institute of Standards and Technology (NIST)...

The porosity of platinum nanoparticles (PtNPs) is explored for the first time using tag-redox coulometry (TRC). This is achieved by monitoring the reduction of the 4-nitrobenzenethiol (NTP)-tagged PtNPs on carbon electrodes via both immobilisation and nanoimpacts. The average charge per impact is measured and attributed to the reduction of NTP adsorbed on individual PtNPs. The number of NTP mol...