The work we describe here is aimed at assisting out-patients affected by insulin dependent diabetes mellitus with an advisory/control algorithm. This advisory/control algorithm incorporates expert knowledge about the treatment of this disease by using Mamdani type fuzzy logic controllers to regulate the blood glucose level (BGL). We proposed two-level architecture for control system. The goal o...

BACKGROUND Clinical and experimental data suggest that the inflammatory response is impaired in diabetics and can be modulated by insulin. The present study was undertaken to investigate the role of insulin on the early phase of allergic airway inflammation. METHODS Diabetic male Wistar rats (alloxan, 42 mg/Kg, i.v., 10 days) and controls were sensitized by s.c. injection of ovalbumin (OA) in...

Achieving good glycaemic control while avoiding hypoglycaemia, in order to delay or prevent the long term complications in patients with type 1 or 2 diabetes mellitus is important. Although, insulin plays a vital role in the management of diabetes, conventional human basal insulins like NPH have certain limitations, which have led to the development of more stable and peak less analogues. Altho...

There is some report about the hypoglycemic effect of Juglans rejia L. leaf in alloxan induced diabetic rats and hypoglycemic effect of its fruit peel administered intra peritoneally. Thirty male Wistar rats divided into five groups, to evaluate the hypoglycemic and pancreas β-cells regenerative effects of oral methanolic extracts of leaf and fruit peel of walnut. Rats were made diabetic by int...

The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed-time NPH insulin. The study included 87 patients with diabe...

BACKGROUND Cystic fibrosis related diabetes (CFRD) with fasting hyperglycemia is found in 15% of adult and 11% of adolescent CF patients. Because of concerns about hypoglycemia, it is not common practice to treat CFRD with 24-hour basal insulin therapy, despite evidence that insulin deficiency may contribute to protein catabolism and have an adverse effect on weight, muscle mass, pulmonary func...

Basal insulin is the first and main component of therapy in patients with type 2 diabetes mellitus (T2DM). Based on shortcomings human NPH advantages provided by long-acting basal analogues, they are recommended for priority use T2DM. The leading factor success titration its dose achievement target range glycemia. Data from clinical trials real practice indicate that simpler algorithms ensure b...

Nephronophthisis (NPH) is a cystic kidney disorder that causes end-stage renal failure in children. Five nephrocystin (nephrocystin-1 to nephrocystin-5) genes, whose function is disrupted in NPH patients, have been identified and data indicate they form a complex at cell junctions and focal adhesions. More recently, the nephrocystin proteins have also been identified in cilia, as have multiple ...