Ribosomally synthesized and post-translationally modified peptides (RiPPs) form a highly diverse class of natural products, with various biotechnologically clinically relevant activities. A recent increase in discoveries novel RiPP classes suggests that currently known RiPPs constitute just the tip iceberg. Genome mining has been driving force behind these discoveries, but remains challenging d...

In recent years, there has been a rapid proliferation of novel tobacco and nicotine products in the market, which have gained popularity among adolescents. The prevalence ever users electronic cigarettes (e-cigs) Europe those aged 10–24 ranges from 5.5% to 56.6%, with significant variations across countries. Adolescents reported several reasons for e-cig use initiation, including low harm perce...

iii Acknowledgements v Table of