Abstract Introduction: Hypothyroidism usually affects red blood cell line most commonly seen as normochromic normocytic anemia. We present a unique case of patient with pancytopenia in the setting severe hypothyroidism, which improved following IV thyroid hormone replacement. Case: An 85-year-old female history type II diabetes mellitus and hypothyroidism who was admitted for open reduction int...

MONG THE PROBLEMS often confronting the physician treating patients with rheumatoid arthritis is a recalcitrant anemia.’3 It tends to be hypochromic and normocytic, and in many respects it resembles the anemia associated with chronic infection. The patient with rheumatoid arthritis often responds poorly to orally administered iron. A number of studies have been carried out and various conclusio...

C HRONIC ERYTHROCYTIC HYPOPLASIA in adults is a rare entity.’ It was described for the first time in 1922,2 as a progressive normochromic anemia with erythropoietic aplasia of the bone marrow, reticulocytopenia, normal leukopoiesis and thrombopoiesis, and absence of enlarged spleen or lymph nodes. Infections,3 drugs,4 immunologic reactions,5 azotemia,6’ thymic tumors,8’#{176} and an inborn erro...

Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. Case report: A 5-year-old girl was presented with acute blindness following closantel poisoning. She was given mistakenly a dose of 500 mg/day (25mg/kg/day) fo...

The retrospective analysis of 378 medical records inpatients with steatohepatitis (SH) depending on its etiology was performed to identify and study the type anaemic conditions (AC). Among patients SH mixed (including alcoholic) anaemia found in 32.2% cases, alcoholic (ASH) - 36.3%, non-alcoholic (NASH) 22.0 % cases. Macrocytic, hyperchromic prevailed all groups: 47.9%, ASH 56.8%, NASH 71.4%. N...

BACKGROUND Primary myelodysplastic syndrome (MDS) is an acquired clonal disorder of myeloid progenitor cells, characterized by peripheral cytopenias in the presence of hypercellular marrow with dysplastic features. Our aim was to study the demographical and clinicopathological features of adult Pakistani patients with MDS at disease presentation. MATERIALS AND METHODS This single centre study...

Anemia is the most common hematologic abnormality in pregnancy. Maternal anemia associated with adverse fetal, neonatal, and childhood outcomes. This study aims to determine prevalence of anemia, iron deficiency (IDA), severity condition, effect some socio-demographic factors on pregnant women Garmian province. The was conducted among 157 province between 17 49 years old. Participants completed...

Multiple myeloma (MM) is associated with severe normochromic/normocytic anemia. This study demonstrates that the abnormal up-regulation of apoptogenic receptors, including both Fas ligand (L) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), by highly malignant myeloma cells is involved in the pathogenesis of the ineffective erythropoiesis and chronic exhaustion of the erythr...

A 57 year old female came with the complaint of recurrent headache, often fatigue, and sometimes feel numbs and rigid in her extremities, no other symptom was noted. Her body weight is stable and she was in menopausal state. She had a history of partial thyroidectomy 20 years ago and continues thiamazole 2.5 mg with seldom regular consult to physician. From the physical examination, the patient...

The appearance of a spontaneous carcinoma in an untreated male golden hamster has provided us with a very useful additional experimental model with which to study the anemia of malignancy. The tumor, probably of salivary gland origin, has been serially transplanted in the cheek pouch or flank of normal hamsters through 70 trans plant generations. The growth characteristics are stable and predic...