clinicians should be aware of new developments to familiarize themselves with pharmacokinetic and pharmacodynamic characteristics of new anticoagulant agents to appropriately and safely use them. for the moment, cardiologists and other clinicians also require to master currently available drugs, realizing the mechanism of action, side effects, and laboratory monitoring to measure their anticoag...

background: warfarin is an effective oral anticoagulant which exert its effect by blocking the utilization of vitamin k. warfarin therapy requires ongoing monitoring using the international normalized ratio (inr). in this study, effect of modest increase in vitamin k intake from vegetables on inr values was evaluated in warfarin treated patients. methods: a single-center study involving 24 outp...

Abstract The distance matrix

Let G be a minimal imperfect P 5-free graph (i.e. a minimal imperfect graph not containing a path on 5 vertices as induced subgraph) and let S be a minimal cutset of G. In this paper we study several properties of such cutsets, in particular we prove that the subgraph induced by S is connected, contains a P 4 , cannot induce a bipartite subgraph of G .... As a by-product we also give a structur...

The work is performed in close cooperation with the University of Tromsø and professor Eiliv Lund and is financed by the ERC TICE project. This note describes the preprocessing steps of gene expression data and focuses particularly on the filtering and normalization steps as the choices made here greatly affects the set of probes used in later analyses. In the filtering step, two parameters are...

BACKGROUND In acute stroke patients, thrombolysis is one gold standard therapy option within the first four hours after the ischemic event. A contraindication for thrombolysis is an International Normalized Ratio (INR) value >1.7. Since time is brain, rapid and reliable INR results are fundamental. Aim was to compare INR values determined by central laboratory (CL) analyzer and Point-of-Care Te...

This paper presents a novel and scalable experimental platform for biomechanical analysis of tissue cutting that exploits a triaxial force-sensitive scalpel and a high resolution vision system. Real-time measurements of cutting forces can be used simultaneously with accurate visual information in order to extract important biomechanical clues in real time that would aid the surgeon during minim...

Graph construction is a crucial step in spectral clustering (SC) and graph-based semi-supervised learning (SSL). Spectral methods applied on standard graphs such as full-RBF, ǫ-graphs and k-NN graphs can lead to poor performance in the presence of proximal and unbalanced data. This is because spectral methods based on minimizing RatioCut or normalized cut on these graphs tend to put more import...