The composite likelihood (CL) is amongst the computational methods used for estimation of high-dimensional multivariate normal (MVN) copula models with discrete responses. Its advantage, as a surrogate method, that based on independence univariate marginal regression and non-regression parameters pairwise correlation parameters. Nevertheless, efficiency CL method estimating can be low. For resp...

background: due to difficulty of obtaining a 24h urine (especially in children), a random urine calcium sample is recommended to detect of hypercalciuria. however, recent studies have shown that the urinary calcium/creatinine ratio varies with age and geographic areas. so, the aim of this study was determining the normal value of urinary calcium to creatinine ratio in healthy adolescent’s child...