A considerable amount of evidence collected from several different experimental systems indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in persons taking aspirin or other nonsteroidal antiinflammatory drugs on a regular basis. One property shared by all of these dru...

Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is known to be actively involved in the neuroinflammatory events leading to neuronal death after ischemia. Two isoforms of COX, termed COX-1 and COX-2, have been identified. Unlike COX-1, COX-2 expres...

On the basis of an A-normal form intermediate language we formally specify resource allocation in a compiler for a strict functional language. Here, resource is to be understood in the most general sense: registers, temporaries, data representations, etc. All these should be (and can be, but have never been) speciied formally. Our approach employs a non-standard annotated type system for the fo...

  Data envelopment analysis (DEA) is a nonparametric approach to evaluate theefficiency of decision making units (DMU) using mathematical programmingtechniques. Almost, all of the previous researches in stochastic DEA have been usedthe stochastic data when the inputs and outputs are normally distributed. But, thisassumption may not be true in practice. Therefore, using a normal distribution wi...

Prostanoids may be involved in bradykinin (BK)-induced bronchoconstriction in asthma. We investigated whether cyclooxygenase (COX)-2 induction was involved in prostaglandin (PG) E2 release by BK in cultured human airway smooth muscle (ASM) cells and analyzed the BK receptor subtypes responsible. BK stimulated PGE2release, COX activity, and COX-2 induction in a concentration- and time-dependent ...

The synthesis of prostanoids is regulated by cyclooxygenases (prostaglandin H synthases), which catalyze the conversion of arachidonic acid to PGH2. Cyclooxygenases are the target of aspirin and other nonsteroidal anti-inflammatory agents. In this study, we found that human polymorphonuclear leukocytes (PMNs) express the inducible isoform of cyclooxygenase, COX-2, when stimulated by LPS whereas...

OBJECTIVE Activation of the cyclooxygenase (COX) pathway with secondary neurovascular deficits are implicated in the pathogenesis of experimental diabetic peripheral neuropathy (DPN). The aim of this study was to explore the interrelationships between hyperglycemia, activation of the COX-2 pathway, and oxidative stress and inflammation in mediating peripheral nerve dysfunction and whether COX-2...

Many real data sets contain numerical features (variables) whose distribution is far from normal (gaussian). Instead, their often skewed. In order to handle such it customary preprocess the variables make them more normal. The Box-Cox and Yeo-Johnson transformations are well-known tools for this. However, standard maximum likelihood estimator of transformation parameter highly sensitive outlier...

Abstract The selective inhibition of enzymes that catalyze the conversion arachidonic acid to inflammatory eicosanoids represents a promising approach for cancer therapy. This study, therefore, focuses on incorporation metabolically stable, sterically demanding, and hydrophobic carboranes into existing dual cycloxygenase‐2 (COX‐2)/5‐lipoxygenase (5‐LO) inhibitors are key in biosynthesis eicosan...