The specific characteristic of classification of medical documents from the MEDLINE database is that each document is assigned to more than one category, which requires a system for multilabel classification. Another major challenge was to develop a scalable method capable of dealing with hundreds of thousand of documents. We proposed a novel system for automated classification of MEDLINE docum...

In this paper we propose a method to estimate by maximum likelihood the divergence time between two populations, specifically designed for the analysis of nonrecurrent rare mutations. Given the rapidly growing amount of data, rare disease mutations affecting humans seem the most suitable candidates for this method. The estimator RD, and its conditional version RDc, were derived, assuming that t...

The causes of kidney allograft loss remain unclear. Herein we investigated these causes in 1317 conventional kidney recipients. The cause of graft loss was determined by reviewing clinical and histologic information the latter available in 98% of cases. During 50.3 +/- 32.6 months of follow-up, 330 grafts were lost (25.0%), 138 (10.4%) due to death with function, 39 (2.9%) due to primary nonfun...

A new generic dynamical phenomenon of pseudochaos and its relevance to the statistical physics both modern as well as traditional one are considered and explained in some detail. The pseudochaos is defined as a statistical behavior of the dynamical system with discrete energy and/or frequency spectrum. In turn, the statistical behavior is understood as time–reversible but nonrecurrent relaxatio...

Cytogenetic analysis of short-term cultures was carried out on 109 lipomas from 92 patients. Clonal chromosomal abnormalities were pres ent in 50% of the tumors analyzed. Based on the results, three main Cytogenetic groups were identified and included: (a) tumors with normal karyotypes, (b) tumors with abnormalities involving region ql3-15 on chromosome 12, and (c) tumors with other clonal aber...

Consider a homogeneous Markov chain with discrete time and with a finite set of states E0, . . . , En such that the state E0 is absorbing and states E1, . . . , En are nonrecurrent. The frequencies of trajectories in this chain are studied in this paper, i.e., “words” composed of symbols E1, . . . , En ending with the “space” E0. Order the words according to their probabilities; denote by p(t) ...

The expression of proinflammatory cytokines/chemokines has been reported in in vitro/ex vivo settings of chronic venous insufficiency (CVI), but the identification of circulating mediators that might be associated with altered hemodynamic forces or might represent innovative biomarkers is still missing. In this study, the circulating levels of 31 cytokines/chemokines involved in inflammatory/an...

PURPOSE The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers. MATERIALS AND METHODS 22 KCOTs were evaluated retrospectively. The actual proliferative activity of the ...

Chromosomal insertions are genomic rearrangements with a chromosome segment inserted into a non-homologous chromosome or a non-adjacent locus on the same chromosome or the other homologue, constituting ~2% of nonrecurrent copy-number gains. Little is known about the molecular mechanisms of their formation. We identified 16 individuals with complex insertions among 56,000 individuals tested at B...

We present a method for automated, empirical calibration of freeway traffic flow characteristics. The method uses 5-min flow and density values for a section of freeway and rapidly and reliably estimates key parameters such as free flow speed, capacity, critical density, congestion wave speed and jam density, which are key inputs to many macroscopic traffic simulation models. The method consist...