It remains unclear how the signals of mutant KRASG12 in the transformed cells spread to the surrounding non-mutated cells and changes the microenvironment to promote tumor formation. We identified that Williams-Beuren syndrome transcription factor (WSTF), a non-secretory protein, was released in complex with secretory protein-neuregulin-3 (NRG3). The KRASG12 mutant activates the transcription o...

In the study reported here, non-histamine chromosomal proteins from proliferative and secretory human endometrium, and from undifferentiated endometrial carcinoma have been separated into more than 750 protein components, using a new preparative and highly sensitive analytical method. The following experimental procedure was applied: 1. Dissociation of chromatin under different conditions (vari...

Oenocytes are large secretory cells present in the abdomen of insects known to synthesize very-long-chain fatty acids produce hydrocarbons and pheromones that mediate courtship behavior adult flies. In recent years, oenocytes have been implicated regulation energy metabolism. These hepatocyte-like accumulate lipid droplets under starvation can non-autonomously regulate tracheal waterproofing ad...

The unidirectional fluxes of CIand Na + across the frog gastric mucosa in vitro were investigated with radioactive isotopes, and related to the secretory and electrical properties of the normal, and metabolically inhibited, mucosa. The flux of C1from nutrient to secretory surface of the mucosa was observed to rise sharply with increasing acid secretion, while the corresponding flux of Na + did ...

The hormonally driven expression and cell-specific localization patterns of the progesterone receptor membrane components (PGRMC1 and PGRMC2) in the macaque endometrium during the menstrual cycle are unknown. Additionally, the expression and localization patterns of PGRMC1 and PGRMC2 in the secretory eutopic endometrium of primates afflicted with endometriosis are also unknown. Therefore, we us...

The unidirectional fluxes of CIand Na + across the frog gastric mucosa in vitro were investigated with radioactive isotopes, and related to the secretory and electrical properties of the normal, and metabolically inhibited, mucosa. The flux of C1from nutrient to secretory surface of the mucosa was observed to rise sharply with increasing acid secretion, while the corresponding flux of Na + did ...

Background: Neem leaves (Azadirachta indica L.) have been used for many therapeutic purposes and medicinal applications. The extract of this plant has been used in both male and female genders as a traditional agent to prevent early pregnancy. In this study, the effect of this extract was investigated histologically and morphometrically on the germinal epithelia of the seminiferous tubules, epi...

The unidirectional fluxes of Cl(-) and Na(+) across the frog gastric mucosa in vitro were investigated with radioactive isotopes, and related to the secretory and electrical properties of the normal, and metabolically inhibited, mucosa. The flux of Cl(-) from nutrient to secretory surface of the mucosa was observed to rise sharply with increasing acid secretion, while the corresponding flux of ...